Turmeric Processes a Strong Anti-Inflammatory Activity

By Kyle J. Norton

Inflammation is a systematic immune response during the acute phase of infection.

Macrophages are one of the lymphocytes and the first-line defense of the immune system.

Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.

Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nerves system, the immune first line of defense stimulates the production of blood platelets to the cover the site of damage and pro-inflammatory to kill off pathogens that try to enter the body through the wound or damaged tissue.

Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.

However, in some cases, overexpression of proinflammatory cytokines can cause the death of nearby healthy cells, leading to abnormal skin healing and the formation of irreversible scars.

Chronic inflammation is a result of a prolonged period of inflammation that lasts for several months and even years caused by the inability of the immune system to kill off all harmful microorganisms during the acute phase of infection.

Low-grade inflammation is a different type of chronic inflammation characterized by a production of the inflammatory cytokines in a low-grade state.

Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.

Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin) and other prescription NSAIDs.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the prevention and treatment of chronic inflammatory diseases, researchers examined the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmerone on chronic inflammation.

The randomized double-blind placebo-controlled study included middle-aged and elderly subjects aged 50-69 years with overweight or prehypertension/mild hypertension assigned to consume 900 mg WEC tablets, containing 400 μg bisacurone, 80 μg turmeronol A and 20 μg turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks.

Based on the experimental results, WEC treatment group showed a significant decrease in the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 associated with WEC anti-inflammatory activities.

Furthermore, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, and higher serum levels of high-density lipoprotein cholesterol, compared to the placebo group. 

Moreover, according to the SF-36 score and PMOS and, WEC also improved the general health, vitality, mental health, mental summary component and mood states (vigor-activity and friendliness, respectively.

Based on the results, researchers said, "WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health".

Taken altogether, turmeric used alone or a combination with other phytochemicals may be considered supplements for the prevention and treatment of chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial by Uchio R1, Muroyama K2, Okuda-Hanafusa C2, Kawasaki K2, Yamamoto Y2, Murosaki S. (PubMed)