Leukemia is a medical condition caused by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myeloid or lymphoblastic leukemia.
Bone marrow is the soft tissue inside the hollow center of the major bone, including the spine, pelvis, underarm, leg...
Chronic myeloid leukemia (CML) is a medical condition associated with the overgrowth of immature cells that started in the blood-forming cells of the bone marrow.
More precisely, chronic leukemia is a disease characterized by a slow but still excessive build-up of relatively immature abnormal white blood cells.
Chronic leukemia has a tendency to spread slowly to other parts of the body through the bloodstream and/or lymphatic system.
Chronic leukemia has a tendency to spread slowly to other parts of the body through the bloodstream and/or lymphatic system.
In other words, compared to normal cells that will die after a limited cell division, chronic myeloid leukemia cells continue to divide with no meaning of dying or stopping, leading to proliferation that affects other healthy cells in the bone marrow.
At the advanced stage, chronic myeloid leukemia cell can leak to the bloodstream, leading to secondary metastasis, depending on the infected tissues and organs.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 8,990 new cases will be diagnosed with CML (5,250 in men and 3,740 in women. and CML is expected to cause the death of 1,140 people including 660 men and 480 women.
More precisely, CML accounts for 15% of all cases of leukemia diagnosed each year. In other words, the lifetime risk of CML in the US is 1 person in 526.
The 5-year survival rate of patients treated with chemo drug imatinib (Gleevec®) including all stages of CML is 90%.
On finding a natural ingredient for the prevention and treatment of leukemia, scientists examined the effects of Costunolide, a sesquiterpene lactone, a small molecular monomer extracted from Inula helenium on K562/ADR chronic myeloid leukemia cells.
Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia.
Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia.
The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.
According to tested analysis,* Costunolide dramatically enhanced doxorubicin-induced antiproliferative activity against K562/ADR cells through inhibition of PI3K/Akt pathway associated with cancer cell proliferation.
* Costunolide combined with doxorubicin also causes cancer cell death by activating the pro-apoptotic proteins aspases 3, cleavage of poly (ADP-ribose) polymerase.
* Moreover, P-glycoprotein expression, a marker for chemotherapy resistance was also inhibited by the injection of Costunolide.
Based on the results, researchers suggest, " These results demonstrate that Costunolide may be a potent therapeutic agent against CML".
Taken altogether, Dandelion may be considered a remedy for the treatment of chronic myeloid leukemia, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Costunolide enhances sensitivity of K562/ADR chronic myeloid leukemia cells to doxorubicin through PI3K/Akt pathway by Cai H1, Li L1, Jiang J1, Zhao C1, Yang C. (PubMed)
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