Saturday 8 February 2020

Kale (Brassica Oleracea) Processes Anti Melanoma Activity in Vitro

By Kyle J. Norton

Skin, a large organ that forms the out layers of our body has serval layers of ectodermal tissue and protects the underlying muscles, bones, ligaments and internal organs against foreign pathogenic invasion.

Skin cancer is a medical condition characterized by disordered and irregular cell growth in the skin.

Most cases of primary skin cancer start in the cell on the surface of the inner ling of the skin. At the advanced stage, the cancerous cells can travel a distance away from the skin to infect other healthy tissue and organ through blood and fluid circulation.

There are 3 main types of cells in the top layer of the skin (called the epidermis):
Squamous cells, Basal cells, and Melanocytes.

Long-term cumulative sun exposure is one of the major causes of basal cell and squamous cell skin cancer. Exposure to ultraviolet (UV) radiation is the leading cause of melanoma.

Melanoma is a kind of skin cancer but less common to other skin cancer as a result of malignancy of melanocytes, which is the cell produced dark pigment for your skin.

Approximate 120,000 new cases of melanoma in the US are diagnosed in a year. melanoma tends to spread along the skin in most of the cases, but also can grow down to the deeper layers of the skin. At the later stage, it can spread to distant parts of the body, including organs.

Certain risk factors that make some people susceptible to the development of skin cancer than others, include the increase in age, weakened immune system, gender, skin tone, genetic preposition, and family history.

Kale is a species of Brassica Oleracea, belong to the family Brassicaceae, native to coastal southern and western Europe. Since kale's leave is highly nutritious and easy to grow with a range of long season from the middle of winter through the beginning of spring, it is cultivated as foods in most parts of Europe.

On finding a potential wholefood for the treatment of skin cancer, researchers examined the effect of kale juice prepared and added to melanoma, epithelial, and fibroblast cells.

According to the results of the analysis, all three juices made with an electric juicer, showed significant anti-cancer activity against B16F10 melanoma cells a dose-dependent decrease.

However, the growth rate of cells treated with an equivalent amount of unfiltered lettuce juice was not different from the untreated cells.

The sonicated and filter-sterilized extract also significantly reduced growth but had different effects on melanoma and epithelial cells. 

Compared to non-cancerous cell lines and other juices, the kale juice was found to be non-toxic to the epithelial cells and the fibroblasts at the dosage that kills melanoma cells. 

Furthermore, kale juice was the most effective by decreasing cancer cell growth with the lowest concentration.

Taken altogether, kale juice may be considered a functional food for the prevention and treatment of melanoma, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of curly kale Brassica oleracea var. sabellica on viability of cultured mouse melanoma cell
by Qizilbash, Bilal Murad, M.S., Mississippi College, 2015, 50; 1605274. (PADT Open)

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