Coltsfoot(Tussilago farfara) Inhibits the Parameters Associated with the Onset of Sepsis

By Kyle J. Norton

Sepsis is a medical condition caused by chemicals released into the bloodstream to fight the infection that triggers inflammation throughout the body as a result of severe infection. 

According to the study by the University of Utah, the disease is the commonest cause of admission to medical ICUs across the world. 

Mortality from sepsis continues to be high. Besides shock and multi-organ dysfunction occurring following the intense inflammatory reaction to sepsis, complications arising from sepsis-related immunoparalysis contribute to the morbidity and mortality from sepsis.

Most common symptoms of sepsis are

* Chilly periphery, fever, jaundice, platelet, and hemoglobin

* Abnormalities of blood pressure, respiration, temperature, and heart rate, and less well-known changes in heart rate variability

* Significantly decreased urine output but accumulative fluid balance had a weak correlation with delta sequential organ failure assessment score (r = 0.32, P = 0.001) and lung injury score (r = 0.13, P = 0.02) and negative correlation with PaO2/FIO2 ratio (r = -0.28, P = 0.001).

* Abrupt change in mental status, difficulty breathing and abnormal blood circulation.

According to the statistics from the CDC, approximately 1.7 million adults in America were infected by sepsis, leading to the death of 270,000 Americans every year.

Sadly, 1 in 3 patients who die in a hospital has sepsis.

Early recognition of sepsis and septic shock in children relies on obtaining an attentive clinical history, accurate vital signs, and a physical examination focused on mental status, work of breathing, and circulatory status, according to the study by the University of Colorado School of Medicine.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of life-threatening infection, researchers examined the Tussilagone, extracted from Tussilago farfara inhibitory effects on puncture (CLP)-induced mouse model of sepsis.

According to the tested differentiation, the extracts at 1 mg/kg and 10 mg/kg showed a significant effect on decreased mortality and lung injury in CLP-activated septic mice.

Enzyme and proteins associated with the production of inflammatory expressions such as cyclooxygenase (COX)-2 and TNF-α in tested septic mice were also attenuated by Tussilago administration. 

Furthermore, CLP induced expression of nitric oxide, prostaglandin E2, TNF-α and HMGB 1 associated with inflammatory cytokines in the serum of the septic mice was also suppressed the administration of the extract.

Based on the findings, researchers said, "Overall, Tussilago exhibited protective effects against inflammation and polymicrobial sepsis by suppressing inflammatory mediators possibly via the inhibition of NF-κB activation and the MAP kinase pathway.".

Taken altogether, coltsfoot may be considered a remedy for the treatment of disease associated with sepsis, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Thyroid Disease: Euthyroid sick syndrome as a result of Sepsis - The Symptoms by Kyle J. Norton
(2) Tussilagone Inhibits the Inflammatory Response and Improves Survival in CLP-Induced Septic
Mice by Kim YK1, Yeo MG2, Oh BK3, Kim HY4, Yang HJ5, Cho SS6, Gil M7, Lee K. (PubMed)