Coffee consumption may have a strong association to potential risk of bladder cancer development,
some scientists suggested.
Bladder cancer is medical condition of cell growth irregularly and disorderly in the bladder. The cancer may spread to distant tissues and organs in the later stage.
Depending to the originated and infected tissue, bladder cancer can be classified into 3 types(4), including
* Transitional cell carcinoma
In early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder beginning in cells in the lining of the bladder.
* Squamous cell carcinoma
Cancer begins in squamous cells in the found in the tissues of the surface of the bladder, due to long-term infection or irritation
* Adenocarcinoma
Cancer begins originates in glandular tissue of the bladder, including the surface layer of skin, glands and a variety of other tissue, due to long-term irritation and inflammation.
Deepening to the stage, patients with bladder can may experience some of the below symptoms, bladder spasms, blood in urine, frequent urination, pain or burning sensation during urination, pain in lower back and/or abdomen, reduced bladder capacity, difficult in urination,.... and common symptoms of loss of appetite and weight.
If you experience some of the symptoms above, please check with your doctor right the way.
Although the single cause of bladder cancer is still debatable, some scientists suggested that smoking,
chemicals exposure, diet high in fried meats and fat, aging are substantial risk factors in development of bladder cancer.
chemicals exposure, diet high in fried meats and fat, aging are substantial risk factors in development of bladder cancer.
* Bladder cancer is the ninth most common cancer in the world.
* Every years over 430,000 new cases are diagnosed in 2012. And
* Men are 4 times more likely to develop bladder cancer in compared to women..
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the Shandong University, in the review literature published online satisfied the criteria and guideline to investigate risk of bladder cancer among coffee consumption adults. Selected studies, numbers of cups/day and relative risk RR as follow
For 23 case-control studies
1. for 1 cup/day, RR=1.07
2 for 2 cups/day, RR=1.15
3 for 3 cups/day, RR=1.22
4. for 4 cups/day RR= 1.29
and
For 5 cohort studies
1. for 1 cup/day, RR=1.09
2. for 2 cups/day, RR=1.13
3. for 3 cups/day, RR= 1.09
4 for 4 cups/day, RR=1.01
The findings in both case-control and cohost studies showed a positive association of coffee intake and risk of bladder cancer.
In non smokers, according to the pooled data set comprises 564 cases and 2929 hospital or population controls enrolled in ten studies conducted in Denmark, Germany, Greece, France, Italy and Spain. risk of bladder caner did not increase monotonically with dose but for heavy coffee drinkers of over 10 cups per days, the risk bladder cancer increases substantially.
Dr. Sala M, the lead author said, "Nonsmokers who are heavy coffee drinkers may have a small excess risk of bladder cancer".
Other, in the analysed a case-control study in two different areas of northern Italy (555 cases and 855 controls), coffee intake and risk of bladder cancer showed that
in compared to non drinkers(RR: relative risk ratio)
1. RR 1.2 for one cup of coffee per day,
2. RR 1.4 for two,
3. RR 1.5 for three and
4 RR 1.4 for four or more
5. RR 1.5 (0.9-2.4) for decaffeinated coffee.
But in never smoked participants, the risk of bladder cancer increased significantly
1 .RR 1.9 for one or two cups per day,
2. RR 1.8 for three and
3 RR 1.5 for four or more
Taking together, there is no doubt that coffee and coffee caffeine consumption have a mild risk in exhibited incidence of bladder cancer regardless to numbers of cups intake daily and regularly.
However, Due to the small size of the studies, some researchers suggested that a sample size of clinical trial with multi centers involved are necessary to rule out or re confirm the side effect of coffee intake possibility.
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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) A dose-response meta-analysis of coffee consumption and bladder cancer by Zhou Y1, Tian C, Jia C.(PubMed)
(2) Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case-control studies in European countries by Sala M1, Cordier S, Chang-Claude J, Donato F, Escolar-Pujolar A, Fernandez F, González CA, Greiser E, Jöckel KH, Lynge E, Mannetje A, Pohlabeln H, Porru S, Serra C, Tzonou A, Vineis P, Wahrendorf J, Boffetta P, Kogevina M.(PubMed)
(3) Coffee consumption and bladder cancer risk by D'Avanzo B1, La Vecchia C, Franceschi S, Negri E, Talamini R, Buttino I.(PubMed)
(4) Bladder Cancer by Kyle J. Norton
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