Thursday, 16 August 2018

* Andrographis Aniculata, The Functional Herb That Works Better Than Antibiotics Against Upper Respiratory Tract Infection

By Kyle J. Norton, Master of Nutrition

Andrographis paniculata may be one of the best herb in inhibited  upper respiratory tract infection, some scientists suggested.

Upper respiratory tract infection is caused by spreading from person to person in respiratory droplets through sneezing or coughing of individual infected with the virus or bacteria.

The disease is the infection of the airway above the glottis or vocal cords, including the nose, sinuses, pharynx, and larynx, tonsillitis, pharyngitis, laryngitis, sinusitis, otitis media,....

Most common disease of upper respiratory infection are common Cold, Sinusitis, Pharyngitis, Epiglottitis and Laryngotracheitis infected by micro organisms including bacteria and virus, leading to symptoms of runny, stuffy nose and sneezing and sometimes fever.

In severe case of infection upper airway infection such as Haemophilus influenzae type B is caused by bacterial Streptococcus pyogenes.

Not all people who comes into direct contact with an ill person will be infected. However, people with chronic ailments and weakened immune system are susceptible to the diseases.
According to the population-based study, conducted between December 2011 and March 2013 in South Baden, Germany. From a total of 69, 695 individuals approached via mail 12, 839 individuals in the age range of 18 to 70 years completed the screening questionnaire, researchers found that  upper respiratory infection is correlated positively with female sex, younger age, and frequent contact to children, smoking status, and obesity as well as a number of co-morbidities, most strongly asthma and chronic obstructive pulmonary disease(4). 

 Antibiotics may be effective for treatment of the disease, however they may induce side effects such gastrointestinal discomforts such as nausea. vomiting. diarrhea and stomach pain, vaginal itching or discharge. headache. rash,.... and tongue swollen.

Moreover, antibiotics may also interact with other prescription and nonprescription medications, including clarithromycin and metoclopramide.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The forgotten herb has been used in traditional Siddha and Ayurvedic for treatment of common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera,.... and pneumonia.

According to the joint study lead by the ilpakorn University in the review of the existence data of the literature and meta-analysis of randomized controlled trials, Andrographis paniculata exerted a strong implication in the symptomatic treatment of uncomplicated upper respiratory tract infection by measuring the reduction in symptom severity scores.

In a total of 433 patients reported in three trials included in the statistical analysis, patients treated with combination of Andrographis aniculata, Acanthopanax senticosus and Andrographis aniculata or alone exhibited a significant improvement of 2.13 points and 10.85 points on the symptom severity score in compared placebo.

Dr. Poolsup N, the lead author said, "A. paniculata extract alone or in combination with A. senticosus extract may be more effective than placebo and may be an appropriate alternative treatment of uncomplicated acute upper respiratory tract infection".

Furthermore, in the review the use of over-prescription of antibiotics related to absence from work due to acute upper respiratory tract infection, researchers found that application A. paniculata are more superior to placebo in alleviating the subjective symptoms of uncomplicated upper respiratory tract infection.

The study also indicated that all review trials scored at least three, out of a maximum of five, for methodological quality on the Jadad scale used to assess the methodological quality of a clinical trial.

More importantly, the efficacy of A. paniculata in relieving symptoms of uncomplicated upper respiratory tract infection only induced generally mild and infrequent adverse effects.

In supporting the Andrographis aniculata's anti upper respiratory tract infection property, an investigation included a total of 223 patients of both sexes randomized in two groups which received either KalmCold (200 mg/day) or placebo in a double blind manner, researcher showed that A. paniculata processes a promising result in ameliorating symptoms of cough, expectoration, nasal discharge, headache, fever, sore throat, earache, malaise/fatigue and sleep disturbance from day 1 to day 3 of treatment in comparison to placebo group.

Additionally, The overall efficacy of extract of Andrographis paniculata was found to be 2.1 times (52.7%) higher than placebo.

Taking together, there is no doubt that Andrographis aniculata has a potency used as therapeutic agent for relieving symptoms and treatment of upper respiratory tract infection but intake of large doses and long term intake should be taken with care.

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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Andrographis paniculata in the symptomatic treatment of uncomplicated upperrespiratory tract infection: systematic review of randomized controlled trials by Poolsup N1, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U.(PubMed)
(2) Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy by Coon JT1, Ernst E.(PubMed)
(3) A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upperrespiratory tract infection by Saxena RC1, Singh R, Kumar P, Yadav SC, Negi MP, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit A.(PubMed)
(4) Screening score to identify people prone to respiratory tract infections in the community by Alexandra Nieters1 *, Susanne Weber2 , Magdeldin Elgizouli3 , Livia Maccioni1 , Stefan Wolfrum1 , Jacques T. Tshiang2 , Ilona Geist1 , Hans-Hartmut Peter1 , Werner Vach2 1 Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freib(Research Article)

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