Aloe Vera may have a potential efficacy in reduced risk and treatment of ulcerative colitis, some scientists found.
Ulcerative colitis is condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract, affecting the function of lining of large intestine (colon) and rectum.
The popular herb has become very popular for commercial cultivation due to its health benefits. Aloe Vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes,..... and elevated of cholesterol.
In a double-blind, randomized, placebo-controlled trial of 44 hospital out-patients with ulcerative colitis randomly given oral aloe vera gel or placebo, 100 mL twice daily for 4 weeks, researchers found that oral administrated group shows an improvement and response occurred in nine (30%), viewed in the Simple Clinical Colitis Activity Index and histological scores.
Dr. Langmead , the lead researcher said, "Oral aloe vera taken for 4 weeks produced a clinical response more often than placebo; it also reduced the histological disease activity and appeared to be safe".
Furthermore, in the study of male Sprague Dawley rats fed experimental diets for 2 weeks before and during the induction of colitis, dietary aloe vera gel significantly ameliorated intestinal inflammatory responses in a dextran sulfate sodium (DSS) induced ulcerative colitis.
In fact, the efficacy is also found to associate to the abundant bioactivity of the herbs.
Other researchers suggested that the anti ulcerative colitis activity of aloe vera gel may be due to the healing properties of antioxidants, scavengers, chelators as well as strongly inhibited inflammation, electrical/mechanical impairment in the gut, and a great majority of oxidative stress.
Taking altogether, herbal aloe vera may process anti ulcerative colitis properties, through expression of bioactivity in induced production of antioxidant and reduced intestinal inflammatory responses. but further study is necessary to re confirm its claim.
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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis by Langmead L1, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, Jewell DP, Rampton DS.(PubMed)
(2) Advances in treatment of ulcerative colitis with herbs: from bench to bedside by Wan P1, Chen H1, Guo Y1, Bai AP1.(PubMed)
(3) Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitismodel by Park MY1, Kwon HJ, Sung MK.(PubMed)
(4) The protective and healing effects of a natural antioxidant formulation based on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative colitis in rats by Korkina L1, Suprun M, Petrova A, Mikhal'chik E, Luci A, De Luca C.(PubMed)
(5) Dietary patterns and risk of ulcerative colitis: a case-control study by Rashvand S1, Behrooz M1, Samsamikor M2, Jacobson K3, Hekmatdoost A(PubMed)
(6) A randomized controlled trial of mindfulness-based stress reduction to prevent flare-up in patients with inactive ulcerative colitis by Jedel S1, Hoffman A, Merriman P, Swanson B, Voigt R, Rajan KB, Shaikh M, Li H, Keshavarzian A(PubMed)