Monday, 9 January 2017

The holistic Prevention, Management and Treatment of Dementia - Phytochemical Silymarin

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

                 Phytochemicals Against Dementia- Silymarin

Phytochemicals, the non nutritional parts are natural chemical constituents in plants to protect against diseases and to form color as well as other organoleptic properties. Study of Phytochemicals have emerged as a potential source to find a better treatment or cure some diseases with little or side effects or to create a synthetic equivalence for commercial profits.

Silymarin is a phytochemical in the class of Lignans (phytoestrogens), found abundantly in artichokes, milk thistle, etc.
1. Antioxidants
Silymarin showed to exert the powerful antioxidant activity into protection of cells against arsenical cytotoxicity(399), via reduced lipid hydroperoxide (LHP) formation with no RNS induction and hepoprotective(400)(401) in ntitubercular and alcohol-induced hepatotoxicity assays in rats(400)

2. Neuroprotective effect
In impaired cognitive and neurochemical function of diabetic patients and streptozotocin induced diabetic rodents, silibinin promoted DNA protection and reduced oxidative stress in a brain specific area, in part via the activation of the HO system(402); In mouse mode with Parkinson's disease(404), treatment of the phytochemical attenuated dopamine levels induced neuro cells damage causes of apoptosis(403) via reduced brain myeloperoxidase activity associated with AD risk(405) and inflammatory signalling cells(404).
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(398) Modulation of early stress-related biomarkers in cytoplasm by the antioxidants silymarin and quercetin using a cellular model of acute arsenic poisoning by Soria EA1, Eynard AR, Bongiovanni GA.(PubMed)
(399) Cytoprotective effects of silymarin on epithelial cells against arsenic-induced apoptosis in contrast with quercetin cytotoxicity by Soria EA1, Eynard AR, Bongiovanni GA.(PubMed)
(400) Hepatoprotective and in vivo antioxidant activities of the hydroethanolic leaf extract of Mucuna pruriens (Fabaceae) in antitubercular drugs and alcohol models by Obogwu MB1, Akindele AJ2, Adeyemi OO1.(PubMed)
(401) Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. by Shaker E1, Mahmoud H, Mnaa S.(PubMed)
(402) Neuroprotective effect of silibinin in diabetic mice by Marrazzo G1, Bosco P, La Delia F, Scapagnini G, Di Giacomo C, Malaguarnera M, Galvano F, Nicolosi A, Li Volti G.(PubMed)
(403) Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease by Pérez-H J1, Carrillo-S C2, García E3, Ruiz-Mar G2, Pérez-Tamayo R4, Chavarría A5.(PubMed)
(404) Neuroprotective effect of pAkt and HIF-1 α on ischemia Liu BN1, Han BX1, Liu F1.(PubMed)

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