Saturday, 14 January 2017

The Conventional Treatments of mild and moderate Alzheimer's disease and Diminished quality of acetylcholine - Anticonvulsants

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

                Treatment of Alzheimer's disease and Diminished quality of acetylcholine

Depending to the causes of disease, most medication are to control the symptoms

3.1. Anticonvulsants
a. Anticonvulsants are a diverse group of pharmaceuticals used in the treatment of seizures(425), chronic neuropathic pain(426), and the clinical syndrome of Alzheimer's disease(427) by suppressing the rapid and excessive firing of neurons(428). Some researchers suggested that seizure pathophysiology may relate to increased amyloid beta-peptide production(429), causing cytoskeletal dysfunction, cerebrovascular changes, neurotransmitter dysfunction or combinations(430). By modification of these pathophysiological pathways, anti-epileptic drugs such as sodium valproate and lacosamide may be useful in the treatment of Alzheimer's disease(431)

b. Side effects are not limit to(432)(433)
b.1. Dizziness
b.2. Drowsiness
b.3. Unsteadiness
b.4. Nausea
b.5. Vomiting
b.6. Skin rashes
b.7. Etc.
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(425) Use of anticonvulsants as prophylaxis for seizures in patients on clozapine by Caetano D1.(PubMed)
(426) Pharmacological management of chronic neuropathic pain: revised consensus statement from the Canadian Pain Society by Moulin D, Boulanger A, Clark AJ, Clarke H, Dao T, Finley GA, Furlan A, Gilron I, Gordon A, Morley-Forster PK, Sessle BJ, Squire P, Stinson J, Taenzer P, Velly A, Ware MA, Weinberg EL, Williamson OD; Canadian Pain Society.(PubMed)
(427) Management of behavioral problems in Alzheimer's disease. BY Gauthier S1, Cummings J, Ballard C, Brodaty H, Grossberg G, Robert P, Lyketsos C.(PubMed)
(428) Synthesis, neuronal activity and mechanisms of action of halogenated enaminones by Edafiogho IO1, Qaddoumi MG2, Ananthalakshmi KV3, Phillips OA4, Kombian SB5.(PubMed)
(429) Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions by Prox J1, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M,Horré K, De Strooper B, Saftig P.(PubMed)
(430) Neurotoxicity of Amyloid β-Protein: Synaptic and Network Dysfunction(PMC)
(431) Epileptic seizures in AD patients. by Larner AJ1.(PubMed)
(432) Anticonvulsant Medication for Bipolar Disorder(WebMD)
(433) Anticonvulsant(Wikipedia)