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Tuesday, 3 January 2017

The holistic Prevention, Management and Treatment of Dementia - Phytochemical Naringenin

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.



                 Phytochemicals Against Dementia- Naringenin

Phytochemicals, the non nutritional parts are natural chemical constituents in plants to protect against diseases and to form color as well as other organoleptic properties. Study of Phytochemicals have emerged as a potential source to find a better treatment or cure some diseases with little or side effects or to create a synthetic equivalence for commercial profits.

Naringenin, a flavanone, belonging to the red, blue, purple pigments of Flavonoids (polyphenols) found predominantly in citrus fruits is considered as one of powerful antioxidant with many health benefits.
1. Antioxidant, free radical scavenging
Naringin showed to reduce DNA damage through its antioxidant capacities in scavenging free radicals hydroxyl and superoxide(317). Cognitively,naringenin ameliorated Alzheimer's disease (AD)-type neurodegeneration(318) by improving learning and memory ability of patient with early onset of the diseases(319). Pharmacologically, the phytochemical was found to be a potential anticancer, antimutagenic, anti-inflammatory, antiproliferative and antiatherogenic agent(320).

2. Anti-inflammatory effects(320)
Neuroinflammation is considered as a constant event in Alzheimer's disease (AD), with no evidences for its direct involvement in development(322). In diabetic mice model, naringenin exhibited its anti inflammatory activity in lowering blood glucose and urea nitrogen, increasing insulin level and
creatinine clearance(321), probably through inhibition of iNOS protein and anti inflammatory pathways(323).

3. Immunity
Adaptive and innate immune deficit were shown to associate with cognitive dysfunction in patients with AD and mild cognitive impairment (MCI)(325).Naringenin, stimulated the production T cells in regulation of the immune system, and in suppression of allergies and autoimmune diseases(324) which are considered as Alzheimer's and Parkinson's disease variants(326).
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References