Sunday, 1 January 2017

The holistic Prevention, Management and Treatment of Dementia - Phytochemicals Rosemarinol

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

                 Phytochemicals Against Dementia- Rosemarinol

Phytochemicals, the non nutritional parts are natural chemical constituents in plants to protect against diseases and to form color as well as other organoleptic properties. Study of Phytochemicals have emerged as a potential source to find a better treatment or cure some diseases with little or side effects or to create a synthetic equivalence for commercial profits.

C.1. Rosemarinol
Rosemarinol is a phytochemical monophenols, found in essential oil of labiate herbs like rosemary and in variety of other plants.
1. Retard autoxidation
Rosemary extract rich in carnosic acid showed a significantly retarded autoxidation, in the fish oil undergoes microencapsulation process(307).

2. Anti-inflammatory effects
The extract of rosemary leaves from supercritical fluid extraction showed a high inhibitory effect on lipid peroxidation, through suppression of the LPS-induced production of nitric oxide (NO)(308) and maintaining oxidative stability(313)

3. Antioxidant defences
Rosemary extract enhanced antioxidant defences and improved antioxidant status in aged rats in attenuation of lipid peroxidation and ROS levels through its antioxidant enzyme activity(309). The extract also showed to exhibit its antioxidant effect against the proliferation of irregular cell growth such as human leukemia and breast carcinoma cells(312).
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(307) Chemical stabilization of oils rich in long-chain polyunsaturated fatty acids during storage by Pop F1.(PubMed)
(308) Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves by Kuo CF1, Su JD, Chiu CH, Peng CC, Chang CH, Sung TY, Huang SH, Lee WC, Chyau CC.(PubMed)
(309) Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged rats by Posadas SJ1, Caz V, Largo C, De la Gándara B, Matallanas B, Reglero G, De Miguel E.(PubMed)
(310) Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol by Dugasani S1, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN.(PubMed)
(311) Gingerol fraction from Zingiber officinale protects against gentamicin-induced nephrotoxicity. by Rodrigues FA1, Prata MM, Oliveira IC, Alves NT, Freitas RE, Monteiro HS, Silva JA, Vieira PC, Viana DA, Libório AB, Havt A.(PubMed)
(312) Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis by Cheung S1, Tai J.(PubMed)
(313) Effects of "nitrendipine" on nitrous oxide anesthesia, tolerance, and physical dependence by Dolin SJ1, Little HJ.(PubMed)

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