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Friday, 13 January 2017

The Conventional Treatments of mild and moderate Alzheimer's disease and Diminished quality of acetylcholine- Antagonist

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.



                Treatment of Alzheimer's disease and Diminished quality of acetylcholine

Depending to the causes of disease, most medication are to control the symptoms

A.2. Treatment of moderate and Severe Alzheimer's disease and Diminished quality of acetylcholine
1. Namenda®(418)(419)(memantine), an N-methyl D-aspartate (NMDA) antagonist(420) are the most common medication used to treat moderate and severe Alzheimer's disease, through it's therapeutic action in uncompetitive binding to the NMDAR for preservance of the physiological function of the receptor(421). But, according to other in 2 out of 3 six month studies, memantine showed only a small beneficial effect but not in patients with vascular dementia(422).

2. Side effects are not limit to(423)(424)
b.1. Confusion
b.2. Dizziness
b.3. Drowsiness
b.4. Headache
b.5. Insomnia,
b.6. Agitation
b.7. Vomiting
b.8. Anxiety


b.9. Etc.

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References
(418) Evaluating high-dose rivastigmine patch in severe Alzheimer's disease: analyses with concomitant memantine usage as a factor by Grossberg GT, Farlow MR, Meng X, Velting DM1.(PubMed)
(419) A double-blind randomized placebo-controlled withdrawal trial comparing memantine and antipsychotics for the long-term treatment of function and neuropsychiatric symptoms in people with Alzheimer's disease (MAIN-AD). by Ballard C1, Thomas A2, Gerry S3, Yu LM4, Aarsland D5, Merritt C6, Corbett A7, Davison C2, Sharma N2, Khan Z7, Creese B7, Loughlin P6, Bannister C6, Burns A8, Win SN9, Walker Z10; MAIN-AD investigators.(PubMed)
(420) Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data by Parsons CG1, Danysz W, Quack G.(PubMed)
(421) N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease by Olivares D1, Deshpande VK, Shi Y, Lahiri DK, Greig NH, Rogers JT, Huang X.(PubMed)
(422) Memantine for dementia by A Areosa Sastre, F Sherriff, R McShane(Cochran bibrary)
(423) memantine - oral, Namenda (cont.)(Medicinenet.comhttp://www.medicinenet.com/memantine-oral/page2.htm)
(424) Memantine(Wikipedia)