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Saturday, 31 January 2015

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): TCM treatments of Dementia Caused by Kidney Qi Deficiency

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By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                     Diseases of Central Nervous system


                             Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
C. In traditional Chinese Medicine Perspective(*)
Based on Chinese ancient medical records, causes of dementia are the results of (810)
C.2. Deficiency of Qi, mainly due to
B.2.1. Kidney Qi deficiency
Kidney Qi  deficiency is a condition of the inability of kidney in expelling extra fluid in the body through urinary secretion via bladder, cause of fluid retention. If the fluid accumulation(a) or hydration(b) occurs in the brain(a) in a prolong period of time, these possibilities can induce abnormal function of neurons in information transmitting or gradual death of brain's neurons(c), leading cognitive impairment, including dementia. In elders, kidney Qi deficiency may also be related to gradual depletion of kidney essences(Jing) due to aging, according to traditional Chinese medicine.
Chinese herbs used to treat kidney Qi  deficiency include
1. Lu rong
Lu rong is also known as deer antler, deer antler velvet,  used in traditional Chinese medicine to reduce the blockage of the meridian liver and kidney for treatment of rheumatoid arthritis(811), osteoarthritis(812), sexual function(813)(814), and sporting performance enhancement(810)(815) by enhancing the yang energy(815). Since qi deficiency is also related to  blood deficiency(816), improving the body yang by strengthening the liver's function in blood formation(816) and kidney's function in fluid distribution(817), showed to reduce the yang deficiency in the body. In neuroprotective effect, deer antler extract  prevented glutamate-induced oxidative stress of reactive oxygen species and lipid peroxidation causes of neurodegenerative disorders(832).

2. Du Zhong
Du Zhong, also known ecommia bark, is one the most used herb to enhance the function of meridian kidney-liver by promoting the qi and blood formation. The liver is a organ in charge of blood storing and blood formation(818) and kidney is in charge of fluid regulation(817), administration of the du zhong promotes kidney yang  through action of harmony in increasing blood flow(819) and reducing fluid accumulated(820) in the body (821).  In learning and memory deficits mice caused by oxidative stress, du zhong significantly improved the impairment of short-term or working memory and reversed learning and memory deficits(833), through inhibited acetylcholinesterase (AChE) activity in a dose-dependent manner (834) and oxidative stress causes of neuronal cell death(835)

3. Ba Ji Tian
Ba ji tian, is also known as Chinese morinda root with sweet and warm in nature. used in TCM to strengthen the liver(823) and kidney qi(822) and blood yang(824) in enhancing the liver in blood formation and kidney in urinary secretion, According to Academy of Military Medical Sciences, ba ji tian showed a strong anti antidepressant activities through its phytochemicals succinic acid, nystose, 1F-fructofuranosylnystose, inulin-type hexasaccharide and heptasaccharide(836)(837).

4. Rou Chong Rong
Rou Chong Rong is also known as Herba Cistanche used in traditional Chinese medicine for reducing the blockage of kidney-large intestine meridian(825), by increasing the kidney function in fluid regulation through improved blood circulation(826) assisted urinary secretion and digestive system in moving waste. In  mouse model with learning and memory deficit, rou chong rong extract increased neuronal cell differentiation, neurite length, and synapse formation in  hippocampus, through nerve growth factor (NGF) biological activities, such as preventing neuronal death(838), memory loss, and increases long-term potentiation and learning task(839).

5. Bu Gu Zhi
Bu gu zhi is also known as psoralea fruit used in traditional Chinese medicine in treating blockage of meridian kidney-Spleen(827) by tonifying the yang(828) and increasing the kidney function(829) in assisting the function of lung qi(830) and the function of spleen in qi distribution(831). In stem neoronal study, phytochemicals psoralen, oleanolic acid, and stilbene glucoside found in psoralea fruit exerted it anti cognitive protective effect through promoting self-renewal of neural stem cells NSCs and neuron-like differentiation(840). In rat with Huntington's disease (HD) using 3-NP induced  mitochondrial dysfunction in cultured (PC12) cells, psoralea corylifolia Linn seed extracts, showed significant protective effect against 3-nitropropionic acid (3-NP) induced cytotoxicity(841).

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Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Medicine by Kyle J. Norton 

References
(*) http://www.hindawi.com/journals/ecam/2012/692621/ (a) http://www.ncbi.nlm.nih.gov/pubmed/18479516
(b) http://www.ncbi.nlm.nih.gov/pubmed/24517977
(c) http://www.ncbi.nlm.nih.gov/pubmed/18479516
(810) http://www.ncbi.nlm.nih.gov/pubmed/23321886
(811) http://www.ncbi.nlm.nih.gov/pubmed/12003439
(812) http://www.ncbi.nlm.nih.gov/pubmed/21750784
(813) http://www.ncbi.nlm.nih.gov/pubmed/15949530
(814) http://www.ncbi.nlm.nih.gov/pubmed/23475732
(815) http://www.chineseherbshealing.com/deer-antler-velvet/
(816) http://www.ncbi.nlm.nih.gov/pubmed/24187879
(817) http://tcmbasics.com/zangfu_5zang_kidney.htm
(818) http://www.innerbody.com/image_digeov/card10-new2.html
(819) http://www.ncbi.nlm.nih.gov/pubmed/25244772
(820) http://www.dallasacu.com/articles/chinese-herb-pictures/eucommia-bark/
(821) http://fourflowerswellness.com/EAM/du-zhong/
(822) http://www.tcmwiki.com/wiki/ba-ji-tian
(823) http://www.americandragon.com/Individualherbsupdate/BaJiTian.html(824http://www.yinyanghouse.com/theory/herbalmedicine/ba_ji_tian_tcm_herbal_database
(824) http://cm-cure.com/Rou-Cong-Rong-Chinese-herbs
(825) http://herbprime.com/Cistanche%20Capsules%20(Rou%20Cong%20Rong%20)(NONE%20CITES)
(826) http://menstruationdisorders-51.blogspot.com.au/2009/11/overcome-infertility-how-to-treat.html
(827) http://www.tcmwiki.com/wiki/bu-gu-zhi
(828) http://qiherbs.com/bu-gu-zhi.html
(829) http://plantcures.com/buguzhi.html
(830) http://www.yinyanghouse.com/theory/herbalmedicine/bu_gu_zhi_tcm_herbal_database
(831) http://fourflowerswellness.com/EAM/bu-gu-zhi/
(832) http://www.ncbi.nlm.nih.gov/pubmed/24460377
(833) http://www.ncbi.nlm.nih.gov/pubmed/24404337
(834) http://www.ncbi.nlm.nih.gov/pubmed/20974223
(835) http://www.ncbi.nlm.nih.gov/pubmed/24440915
(836) http://www.ncbi.nlm.nih.gov/pubmed/7626209
(837) http://www.sciencedirect.com/science/article/pii/S0091305701007304
(838) http://www.ncbi.nlm.nih.gov/pubmed/20849880
(839) http://www.ncbi.nlm.nih.gov/pubmed/19788912
(840) http://www.ncbi.nlm.nih.gov/pubmed/25509270
(841) http://www.ncbi.nlm.nih.gov/pubmed/25277760