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Thursday, 22 January 2015

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Herbal Treatments: Bacopa

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
A. In herbal medicine perspective
5. Bacopa
Commonly known as Waterhyssop or Water Hyssop, the herb is a semi-woody plants, genus of Hyssopus, belonging to the family Lamiaceae, native to the east Mediterranean to central Asia, used in traditional medicine as an antibiotic(660)(659), carminative, antispasmodic, antifungal(661), and antiseptic(661)(662) agent and to treat bronchitis(663), asthma(664), digestive ailments(665)(668), insomnia(666), diabetes(667), edema(669)(670), etc.
a. Increases Cerebral Blood Flow 
In cerebral blood flow (CBF), Bacopa monnieri's promoting blood flow through its procognitive effect in comparison via dose-dependent hypotensive actions (671), with Ginkgo biloba and donepezil(671)may be a potential attenuation of dementia, Parkinson's disease, and epilepsy(672).

b. Ethnobotanical treatment
Bacopa, ethnobotanically, may be used as brain tonification(676) and to treat various diseases(673), including Alzheimer's disease
through its phytochemicals in alleviation of AD pathology and associated symptoms(674). According to university System HSC College of Medicine, Bacopa monniera extract (BME), administered starting at 2 months of age for either 2 or 8 months on test mice, significant lowers Abeta 1-40 and 1-42 levels in cortex by as much as 60%, and reverses Y-maze performance and open field hyperlocomotion behavioral changes(675). Its natural products (galantamine and rivastigmine), also has been used pharmaceutically for cognitive and behavioural and psychological symptoms of dementia (BPSD)(673).

c. Cognitive performance, anxiety, and depression 
In olfactory bulbectomized mice, alcoholic extract of Bacopa monnieri (L.) showed to ameliorate memory and emotional deficits(678) and enhanced cognitive performance(679) through its protection of cholinergic systems from OBX-induced neuronal damage(677). In normal healthy participants, the herb also attenuated stress reactivity and mood, through its adaptogenic and nootropic effects, probably via reduction in cortisol levels(680). According to National College of Natural Medicine, standardized dry extract of Bacopa monnieri, promoted the improvement depression scores, combined state plus trait anxiety scores,with few adverse events, primarily stomach(681)

 d. Etc. 


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Sources
(659) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017840/
(660) http://www.ncbi.nlm.nih.gov/pubmed/22733208
(661) http://www.ncbi.nlm.nih.gov/pubmed/?term=Bacopa++antifungal
(662) http://www.ncbi.nlm.nih.gov/pubmed/15022161
(663) http://www.ncbi.nlm.nih.gov/pubmed/?term=Bacopa+asthma
(664) http://www.ncbi.nlm.nih.gov/pubmed/23195581
(665) http://www.ncbi.nlm.nih.gov/pubmed/?term=Bacopa+digestive+ailments
(666) http://www.ncbi.nlm.nih.gov/pubmed/8792640
(667) http://www.ncbi.nlm.nih.gov/pubmed/21154199
(668) http://www.ncbi.nlm.nih.gov/pubmed/15088689
(669) http://www.ncbi.nlm.nih.gov/pubmed/16343831
(670) http://www.ncbi.nlm.nih.gov/pubmed/16343831
(671) http://www.ncbi.nlm.nih.gov/pubmed/22447676 
(672) http://www.ncbi.nlm.nih.gov/pubmed/23772955
(673) http://www.ncbi.nlm.nih.gov/pubmed/22591592
(674) http://www.ncbi.nlm.nih.gov/pubmed/22329652
(675) http://www.ncbi.nlm.nih.gov/pubmed/16914834
(676) http://www.ncbi.nlm.nih.gov/pubmed/7736852
(677) http://www.ncbi.nlm.nih.gov/pubmed/23949198
(678) http://www.ncbi.nlm.nih.gov/pubmed/24646653
(679) http://www.ncbi.nlm.nih.gov/pubmed/23281132
(680) http://www.ncbi.nlm.nih.gov/pubmed/?term=Bacopa+monnieri+adaptogenic+and+nootropic+effects
(681) http://www.ncbi.nlm.nih.gov/pubmed/18611150