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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
C. Phytochemicals Against Dementia
Tyrosol is a phytochemical compound, a derivative of phenethyl alcohol, belongings to the group of tyrosol esters, found mostly in olive oil. The phytochemical is best known for its antioxidants in protecting the forming of free radicals and lipid oxidation causes of heart disease(383).
1. Antioxidant effects
Tyrosol attenuates the elevated cellular concentrations of reactive oxygen species, NO scavenging(386) and lipid peroxidation, against bacterial invasion(386), DNA damage induced by dioxin toxicity(384) and hydrogen peroxide (H2O2)(385) probably through vary antioxidant-dependent mechanisms. Neurologically, tyrosol showed to exhibit its protective effect against dopaminergic neuronal induced degradation(387) and neurotoxicity(388) in vitro model of Parkinson's disease.
2. Alzheimer Disease
In Alzheimer Disease, tyrosol has shown to protect neuro-cells damage against amyloid-β-Induced toxicity, probably through anti inflammatory pathways(389). In women, the phytochemical also exerted its antioxidative activity(391), in removing harmful compounds from the body; reducing risk of bacterial respiratory tract, intestinal, and genital tract infections(392); suppressing LDL(392) causes of the development of cardiovascular disease; and preventing oxidation induced diseases and conditions, such as cardiovascular disorders(392), cancer(392), osteoporosis(393)(394), Alzheimer disease(390)(395)(396)(397).
Silymarin is a phytochemical in the class of Lignans (phytoestrogens), found abundantly in artichokes, milk thistle, etc.
Silymarin showed to exert the powerful antioxidant activity into protection of cells against arsenical cytotoxicity(399), via reduced lipid hydroperoxide (LHP) formation with no RNS induction; and hepoprotective(400)(401) in ntitubercular and alcohol-induced hepatotoxicity assays in rats(400)
2. Neuroprotective effect
In impaired cognitive and neurochemical function of diabetic patients and streptozotocin induced diabetic rodents, silibinin promoted DNA protection and reduced oxidative stress in a brain specific area, in part via the activation of the HO system(402); In mouse mode with Parkinson's disease(404), treatment of the phytochemical attenuated dopamine levels induced neuro cells damage causes of apoptosis(403) via educed brain myeloperoxidase activity associated with AD risk(405) and inflammatory signaling cells(404).
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