Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday 18 April 2019

Phytochemical Indicaxanthin Blocks the Formation of Plague Against the Onset of Atherosclerosis

By Kyle J. Norton

Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.

Depending on the location of the blockage, if the reduced blood flow occurred in the brain, it will cause the death of the brain cells, leading to stroke.

However, if the reduced blood flow occurred in the heart, it will cause damage to the heart tissues, leading to heart disease.

Most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium and other chemical substances in the artery

Most people with atherosclerosis are asymptomatic at the early stage.

Some researchers suggested that atherosclerosis is a lipoprotein-driven disease. Therefore, people with high blood cholesterol are at an increased risk of atherosclerosis. Overuse of calcium supplement is also found to elevated the condition risk, particularly in the elderly.

Other risk factors that have bee found epidemiologically by studies are high blood pressure, triglycerides, smoking, insulin resistance, obesity or diabetes and inflammatory diseases, such as arthritis, lupus or infections.

Most cases of atherosclerosis can be reversed by making a change of lifestyle and moderate exercise.

Dr. Singh RB, the lead scientist wrote, "Adherence to diet and exercise was obtained through questionnaires and information obtained was quantified into a formula. After 24 weeks, the overall score of diet and exercises were significantly higher in group A(intervention diet( than in group B(control). There were a significant decrease in serum total cholesterol (13.3%), low-density lipoprotein cholesterol (16.9%), triglycerides (19.2%), fasting blood glucose (19.5%) and blood pressures (11.5/6.2 mm Hg) in the intervention group compared with initial levels and changes in group B".

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of betacyanins, belonging to the group of betalains, found abundantly in beets, chard, etc.

With an aim to find a natural compound for the treatment of atherosclerosis, researchers at the Università di Palermo investigated the effect of phytochemical indicaxanthin (Ild) a major compound found in beetroot on human atheromas.

7-Ketocholesterol (7-KC)-induced the development of human atheromas, according to the kinetic measurements within 24 h, before injection of indicaxanthin showed the early formation of intracellular reactive oxygen species over basal levels, preceding NADPH oxidase-4 (NOX-4) over-expression and elevation of cytosolic Ca²⁺, involved in reactive oxygen species (ROS) production. and associated with the progressive depletion of antioxidant activity of total thiols.

Furthermore, 7-KC- also induced the expression of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) associated with the production of proinflammatory cytokines and innate and adaptive immune response.

Where 7-Ketocholesterol (7-KC) induced apoptosis of macrophages has been found to elevated the plaque progression and endoplasmic reticulum stress caused by secretion of pro-inflammatory, procoagulant, and proteolytic molecules by macrophages.

Believe it or not, Co-incubation of 2·5 μm of indicaxanthin completely prevented 7-KC-induced pro-apoptotic events.

In other words, indicaxanthin protects the macrophages integrity against apoptosis, thus reducing the risk of plaque accumulated on the wall of the arteries in facilitating the onset of atherosclerosis.

Based on the findings, researchers concluded, "The effects of Ind may be ascribed to inhibition of NOX-4 basal activity and over-expression, inhibition of NF-κB activation, maintaining cell redox balance and Ca homeostasis, with the prevention of mitochondrial damage and consequently apoptosis".

Taken altogether, phytochemical indicaxanthin (Ild) found in beetroot may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of larger sample size and multicenter human study.

Intake of indicaxanthin (Ild) in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress by Tesoriere L1, Attanzio A, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Betalains, the nature-inspired pigments, in health and diseases by Rahimi P1, Abedimanesh S1, Mesbah-Namin SA1, Ostadrahimi A. (PubMed)
(3) Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study by Singh RB1, Singh NK, Rastogi SS, Mani UV, Niaz MA. (PubMed)

Wednesday 17 April 2019

The Herbal Aloe Vera's 30 Health Benefits

By Kyle J. Norton

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

The herb has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.

1. Herbal Aloe Vera, The Natural Anti Non-Insulin Dependent Type II Diabetes Functional Food, Scientist Find
2. Herbal Aloe vera and Acne vulgaris
3. Herbal Aloe Vera, The Potential Cure of Gastric Ulcer With No Side Effects
4. Herbal Aloe Vera Gobbles Up Cancer Cells in Vivo and Vitro
5. Aloe Vera Inhibited Symptoms and Progression of Polycystic Ovarian Syndrome With No Side Effects, According to Studies
6. Herbal Aloe Vera, a Potent Mouth Wash for the Prevention and Treatment of Gingivitis with No Side Effects
7. Herbal Aloe Vera, the Natural Remedy for the Treatment Psoriasis
8. Herbal Aloe Vera, the Potential Anti Irritable Bowel Syndrome Remedy
9. Herbal Aloe Vera, the Promising Anti Skin Diseases Functional Remedy
10. Herbal Aloe Vera, the Promising Topical Wound Healing Functional Remedy, Researchers Say
11. Herbal Aloe Vera Improves the Function of the Immune System with No Side Effects
12.Herbal Aloe Vera, the Anti Skin Aging Functional Remedy with NO Side Effects, According to Studies
13. Herbal Aloe Vera, the Potential Anti Prostate Cancer Functional Remedy
14. Herbal Aloe Vera, the Potent Anti Colon Cancer Herbal Remedy
15. Aloe vera gel (AVG) and Polycystic Ovarian Syndrome (PCOs)
16. Herbal Aloe vera and lung cancer
17. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine for Reduced Aging Wrinkle
18. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine for Treatment of Ulcerative Colitis
19. Herbal Therapy: Aloe Vera, the Anti-Constipation Natural Whole Food Medicine
20. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine in Anti Microbial effects
21. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine to Restore Normal Levels of Cholesterol
22. Herbal Therapy: Aloe Vera, the Neuroprotective Natural Whole Food Medicine
23. Herbal Therapy: Topical Aloe Vera, The best Whole Food Medicine for Treatment of Burn
24. Herbal Therapy: Aloe Vera, The Immunomodulatory Whole Food Medicine
25. Aloe Vera, The Functional Herb Which Processes Anti Hypertensive Potency
26. Herbal Therapy: Aloe Vera, the Natural Whole Food in Inhibited HSV-1(Herpes simplex) Activity
27. Herbal Therapy: Aloe Vera, the Natural Antioxidant Whole Food
28. Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine for Reduced Symptoms and Treatment of Oral Submucous Fibrosis
29. Herbal Aloe Vera Juice, the Potent Mouth Wash for Treatment of Oral Mucositis Caused by Chemo and Radiation Therapy in Patients with Head and Neck Cancer
30. Herbal Aloe vera, the Anti Primary Glioblastoma Functional Remedy

The 18 Health Benefits of Phytochemical Sinigrin

By Kyle J. Norton

Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Whole Food Ginger Suppresses Rheumatoid Arthritis

By Kyle J. Norton

Scientists may have found a kitchen pungent spice for the treatment of rheumatoid arthritis with no side effects, according to studies.

Rheumatoid Arthritis is a chronic disorder characterized by inflammation of the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.

According to the statistics provided by the CDC, musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid arthritis was found to induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.

Patient with rheumatoid arthritis (RA) often associates to valgus deformities of the feet and deformities of gait due to body function due to an effort to support the collapsing longitudinal arch of the foot. The kinematic and kinetic gait changes in rheumatoid arthritis (RA) are the result of a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,...

Long-term bone damage and the prolonged onset of the disease can induce deformities of hand and wrist and small peripheral joints (such as fingers and wrist) due to chronic inflammation.

The effects of muscle strength in patients with RA may contribute to the prevalence of functional limitations physically that can affect daily living and quality of life.

Furthermore, rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with RA.

Moreover, morning stiffness, a marker of inflammatory activity that reflects functional disability and pain is a very common symptom of patients in early stage of rheumatoid arthritis.

Dr. Motl RW and Dr. McAuley E. in the assessment of chronic diseases said, " The rationale and the associated onset of chronic disease conditions that influence function, disability, and quality of life (QOL) are embedded in the "Graying of America""(29), including patients with RA.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists in seeking a potent natural ingredient or compound for the treatment of rheumatoid arthritis investigated ginger's traditional use as an anti-inflammatory against RA in Chinese and Ayurvedic medicine.

In joint swelling in an animal model of rheumatoid arthritis and streptococcal cell, wall-induced researchers compared crude ginger extract and a fraction containing only gingerols and their derivatives.

According to the assays, both extracts were efficacious in preventing joint inflammation.

However, the crude dichloromethane extract, containing essential oils and more polar compounds, was more efficacious in preventing both joint inflammation and destruction, compared to the fraction.

The results strongly suggested the use of ginger extract for the prevention of joint inflammation and destruction in RA.

Dr. Funk JL and colleagues at the University of Arizona wrote, " these data document a very significant joint-protective effect of these ginger samples and suggest that nongingerol components are bioactive and can enhance the antiarthritic effects of the more widely studied gingerols.

In order to reveal more information about ginger anti-RA property, researchers evaluated the anti-inflammatory effects of ginger's other secondary metabolites, the essential oils (GEO), containing terpenes in female Lewis rats with SCW-induced arthritis.

Injection of GEO (28 mg/kg/d ip) prevented chronic joint inflammation, without altering the initial acute phase of joint swelling and granuloma formation at sites of SCW deposition in the liver.

Compared to pharmacologic doses of 17-β estradiol (200 or 600 μg/kg/d sc), GEO elicited the same pattern of anti-inflammatory activity by its phytoestrogenic activity.

Based on the findings, Dr.Funk JL, the lead scientist wrote again in the final report, "ginger's anti-inflammatory properties are not limited to the frequently studied phenolics, but may be attributable to the combined effects of both secondary metabolites, the pungent-tasting gingerols and as well as its aromatic essential oils".

Take all together, ginger processed a high amount of bioactive compounds and secondary metabolites may be considered a functional alternative for prevention and treatment of RA, pending to the confirmation of large sample size and multicenter human study.

Sources
(1) Anti-Inflammatory Effects of the Essential Oils of Ginger (Zingiber officinaleRoscoe) in Experimental Rheumatoid Arthritis by Funk JL1, Frye JB1, Oyarzo JN1, Chen J1, Zhang H2, Timmermann BN. (PubMed)
(2) Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis by Funk JL1, Frye JB, Oyarzo JN, Timmermann BN. (PubMed)
(3) Most Common Disease of the elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Rheumatoid Arthritis: The Signs and Symptoms by Kyle J. Norton

Herbal Artichoke Enhanced Nonpathogenic Intestinal Microflora for the Promotion of Digestive Health

By Kyle J. Norton

Gut microbiota or gastrointestinal microbiota is the complex community of over 10 trillions microorganisms living in our digestive tracts.

Use of antibiotics, diet, drugs, may alter the composition of the microbiota.

Under the normal condition, in healthy individuals, gut microbiota plays a critical role in the modulation of the immune, metabolic and neurobehavioral traits.

In Immunity, gut microbiota stimulates the immune system protective responses to pathogens and the maintenance of tolerance to innocuous antigens.

In metabolism, gut microbiota improve glucose tolerance, mipoprotein profile and atherosclerotic plaque development.

In neurological disease, gut microbiota improved the neuropsychiatric conditions, including depression, autism and Parkinson’s disease.

In other words, the balanced gut microbiota has a strong impact on the protection of our body against abnormal metabolism, infectious diseases, and loss or death of neurons in the initiation of diseases of the central nervous system.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutics for the improvement nonpathogenic intestinal microflora investigated the dried Jerusalem artichoke(JA) effects on microflora and short-chain fatty acids (SCFA) in the hindgut.in male pigs 1 week fed with JA before slaughter.

The study included 5 experimental groups (n = 11) given different dietary treatments 7 days before slaughter: negative control (basal diet), positive control (basal diet + 9% chicory-inulin), basal diet + 4.1% Jerusalem artichoke, basal diet + 8.1% Jerusalem artichoke and basal diet + 12.2% Jerusalem artichoke.

Increasing levels of Jerusalem artichoke to entire male pigs reduced skatole, a mildly toxic compound in digesta from colon and in feces and level of Clostridium perfringens, type of bad bacterias in the gut in both colon and rectum.

Furthermore, injection of JA also increased the total amount of SCFA (linear, P < 0.05), acetic acid (linear, P < 0.05) and valerianic acid (linear, P < 0.01) produced by the friendly bacteria in your gut in feces.

JA improved intestinal microflora by reducing skatole levels through decreasing in C. perfringens and the increase in SCFA with a subsequent reduction in pH.

Taken altogether, artichoke may be considered a functional formula for the improvement of the intestinal microflora, with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Feeding Jerusalem artichoke reduced skatole level and changed intestinalmicrobiota in the gut of entire male pigs by Vhile SG1, Kjos NP, Sørum H, Overland M. (PubMed)
(2) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)

Herbal Bilberry, the Natural Inhibition of Cardiometabolic Risk Factors According to Human Studies

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a whole fruit for the inhibition of cardiometabolic risk factors (CRFs) associated with the onset of cardiovascular disease,, according to studies.

Cardiovascular disease is a class of diseases involving the blood vessels and heart, depending on the location or area that has been affected.

Cardiometabolic risk factors (CRFs) are conditions that cause damage to the heart and blood vessels. Some researchers suggested that cardiometabolic risk factors are a cluster of condition that causes the onset of diabetes, heart disease or stroke.

Cardiometabolic risk factors can be classified by preventable and nonpreventable risks
* Preventable risk factors can be lower by making a change of lifestyle such as following a healthy diet, quitting smoking, losing weight and exercising daily and moderately.

According to epidemiological studies, a healthy lifestyle has been found to reduce risks of metabolic syndrome, a cluster of conditions associated with the cardiometabolic risk, including lower high blood sugar, cholesterol, and pressure.

* Nonpreventable risks are the risk cannot be changed including aging, ethnicity, family history, medical condition,...

Out of a number of risk factors, some researchers suggested that the prevalent obesity may be the major culprit that causes the onset of diabetes and cardiovascular disease in the Western world.

According to the data provided by the Center for Disease Control and Prevention, "Among participants with overweight (52.5% of the sample), 18.6% had none of the 4 CRFs. Among the 47.5% of participants with obesity, 9.6% had none; among participants with morbid obesity, 5.8% had none. Age was strongly associated with CRFs in multivariable analysis".

The results are according to the measurement of elevated blood pressure (systolic ≥130 mm Hg or diastolic >85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0–405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol (<40 mg/dL for men or <50 mg/dL for women or ICD-9-CM 272.5); and prediabetes (fasting glucose 100–125 mg/dL or HbA1c 5.7%–6.4% or ICD-9-CM 790.2x).

The results strongly suggested if you are overweight or obese, you are at an increased risk of diabetes and cardiovascular disease compared to those who do not.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find a natural whole food for the inhibition of cardiometabolic risk factors that increase the risk of CVD and diabetes, researchers examined the effect of baseline metabolome on the overall metabolic responses to berry intake.

The study included 80 overweight women completed the randomized crossover study randomly assigned to consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD) (1:1), or frozen bilberries.for 30 days.

By comparing the metabolic profile that reflected higher cardiometabolic risk(group B) at baseline, and participants who had a lower-risk profile (group A), researchers showed that bilberries caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.

In other words, bilberry exerted a protective effect against people with cardiometabolic risk without causing harm to people with lower risk profiles.

In order to reveal more information about bilberry inhibition of cardiovascular risk factors researchers investigated regular consumption of bilberries effects on CVD risk reduction, such as decreasing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) and increasing high-density lipoprotein cholesterol (HDL-C).

The study involved women (n=25) and men (n=11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks.

During the experiment, the consumption of bilberries led to a decrease in total cholesterol, LDL-C, TG, glucose, albumin, γ-glutamyltransferase, and a positive increase in HDL-C (P=.044). In both women and men.

However, in men, additionally, favorable changes were observed in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C.

Dr. the lead scientist said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".

Taken altogether, bilberry may be considered a functioning remedy for the inhibition of cardiometabolic risk factors and prevention of CVD, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(2) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(3) Cardiometabolic Risk Factors Among 1.3 Million Adults With Overweight or Obesity, but Not Diabetes, in 10 Geographically Diverse Regions of the United States, 2012–2013. ORIGINAL RESEARCH — Volume 14 — March 9, 2017. (CDC)

Phytochemical 3,3'-Diindolylmethane, the Natural Treatment for Breast cancer in Vivo and Human Studies

By Kyle J. Norton

Cancer is a class of diseases in which a group of cells growing and multiplying disorderly and uncontrollably in our body.

Breast cancer (malignant breast neoplasm) is a medical condition characterized by irregular cells growth in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There are also rare cases that breast cancer started in other areas of the breast.

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the US and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Breast cancer is first noticed as a painless lump in the breast or armpit and most often discovered by the women themselves.

In some cases, breast cancer can also be noticed by the woman partner or during the doctor a routine physical exam.

In the early stage of breast cancer, patients may experience symptoms of the lump (mass) in the breast. and in the armpit (lymph nodes), nipple discharge, inverted or retracted nipple, scaly or pitted skin on nipple, persistent tenderness of the breast and unusual breast pain or discomfort.

If you experience some of the aforementioned symptoms, please check with your doctor right the way to rule out the possibility. Breast cancer diagnosed in the early stage have a 5-year survival rate of 100%.

However, at the advanced stage, due to the oversize of the tumor, patients may experience symptoms of bone pain (secondary tumors in bone), shortness of breath (secondary tumors in lung) and Headaches, neurological pain or weakness (secondary tumors in the nervous system) accompanied by the general symptoms shared with other types of cancer.

Out of many risk factor associated with the onset of breast cancer, genetic preposition may be one of the major prediction of the disease.

Dr. Amir Mehrgou, the lead scientist said, "Early detection of mutation carriers in these genes, in turn, can play an important role in its prevention. Because this disease has a high prevalence in half of the global population, female screening of reported mutations in predisposing genes, which have been seen in breast cancer patients, seems necessary. In this review, a number of mutations in two predisposing genes (BRCA1 and BRCA2) that occurred in patients with a family history,..".

In fact, women who carry the BRCA1 and BRCA2 genes have a 68% of lifetime risk to develop breast cancer.

In seeking a potential compound for the treatment of breast cancer, researchers examined the promising 3,3'-Diindolylmethane (DIM) anticancer effects of breast cancer patients with high HER-2/neu levels.

DIM combined with Herceptin enhances the effectiveness of Herceptin by significantly reducing cancer cell viability, and increasing apoptosis-induction and inhibition of colony formation, compared to the use of the chemo drug alone.

The combination also induced cancer cell death by inhibiting the expression of proteins associated with the production of proinflammatory cytokines, cancer cell division and proliferation and migration.

Furthermore, the combination also significantly exhibited the expression of miR-200, which plays an essential in blocking tumor cell invasion and metastasis and reduction of FoxM1 expression in the promotion of cancer cell proliferation.

Dr. Ahmad A, the lead scientist said, "DIM-plus Herceptin therapy could be translated to the clinic as a therapeutic modality to improve treatment outcome of patients with breast cancer, particularly for the patients whose tumors express high levels of HER-2/neu".

Moreover, in order to know more information about DIM anti-breast cancer activity, researchers investigated the bioactive compound against the transcription factor Forkhead Box M1 (FoxM1) associated with aggressive human carcinomas, including breast cancer.

3,3'-diindolylmethane (DIM), a nontoxic dietary chemopreventive agent showed to inhibit the FoxM1 in various breast cancer cell lines, according to the observation of gene transfection, real-time reverse transcription-PCR, and Western blotting.

Similar to the aforementioned results, DIM combined with Taxotere enhanced Taxotere-induced growth inhibition of breast cancer cells and decreased the invasive capacity of breast cancer cells compared to treatment alone.

Most importantly, the combination treatment also significantly inhibited tumor growth in severe immunodeficiency (SCID) mice,

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3, 3'-Diindolylmethane enhances the effectiveness of herceptin against HER-2/neu-expressing breast cancer cells by Ahmad A1, Ali S, Ahmed A, Ali AS, Raz A, Sakr WA, Rahman KM. (PubMed)
(2) 3,3'-Diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1 by Ahmad A1, Ali S, Wang Z, Ali AS, Sethi S, Sakr WA, Raz A, Rahman KM. (PubMed)
(3) The importance of BRCA1 and BRCA2 genes mutations in breast cancer development by Amir Mehrgou 1 and Mansoureh Akouchekian. (PMC)

Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

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Thursday 18 April 2019

Phytochemical Indicaxanthin Blocks the Formation of Plague Against the Onset of Atherosclerosis

Wednesday 17 April 2019

The Herbal Aloe Vera's 30 Health Benefits

The 18 Health Benefits of Phytochemical Sinigrin

Whole Food Ginger Suppresses Rheumatoid Arthritis

Herbal Artichoke Enhanced Nonpathogenic Intestinal Microflora for the Promotion of Digestive Health

Herbal Bilberry, the Natural Inhibition of Cardiometabolic Risk Factors According to Human Studies

Phytochemical 3,3'-Diindolylmethane, the Natural Treatment for Breast cancer in Vivo and Human Studies