Wednesday 2 September 2020

Herbal Ashwagandha Processes Anti Chronic Inflammatory Diseases Activity

By Kyle J. Norton

Chronic diseases are medical conditions that last more than 3 months depending on the type of diseases.

In other words, chronic diseases generally cannot be prevented or cured by medication, nor do they just disappear.

According to the statistics, chronic diseases affect millions of people worldwide, leading to the death of 35 million people in 2005, including many young people and those in middle age.

The most common types of chronic diseases include cardiovascular diseases, stroke, cancer, chronic respiratory diseases, diabetes, and mental disorders.

Inflammation is a process of the immune system that responds to harmful pathogens.

Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.

However, in some cases, the overproduction of proinflammatory cytokines may damage nearby healthy cells and tissues, causing the formation of scars.

In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal condition also switch to produce pro-inflammatory cytokines.

Most cases of acute inflammatory are resolved within a few days without causing damage to the wound tissues.

Chronic inflammatory diseases are the results of the immune system response inability to kill off all infectious pathogens during the acute phase of infection, leading to the immune adaptation to the new change.

In some cases, chronic diseases also are caused by the immune system mistakenly attacking the bodily tissue, leading to low-grade inflammation such as rheumatoid arthritis.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound that processes the chronic diseases, researchers examined the effects of Withanolides, and in particular extracts from Withania somnifera pharmacologic properties on chronic inflammatory diseases.

According to the tested analysis, withanolides exerted a strong anti-inflammatory activity by inhibiting the inflammatory pathways such as NF-κB, JAK/STAT in the production of pro-inflammatory cytokines in inducing chronic illnesses.

The results of withanolides efficacy in reducing the onset of chronic disease was attributed to its activity in mediating the process of proteins associated with the induction of pro-inflammatory pathways against chronic diseases including arthritis, autoimmune, cancer, neurodegenerative, and neurobehavioral.

Additionally, these naturally derived compounds also were found to exhibit remarkable biologic activity across these complex disease processes with only minimal adverse effects.

Based on the results, researchers said, " As novel compounds and analogs continue to be discovered, characterized, and clinically evaluated, the interest in withanolides as a novel therapeutic only continues to grow".

Taken altogether, Ashwagandha may be considered a functional herb for the treatment of chronic inflammatory diseases including Parkinson's disease, Alzheimer's disease, pending to the result of larger sample size and multicenter study

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Natural Withanolides in the Treatment of Chronic Diseases by White PT1, Subramanian C1, Motiwala HF1, Cohen MS. (PubMed)

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