Thursday 24 September 2020

Cabbage Kills Pancreatic Cancer Cells in Vitro

By Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen.

By secreting pancreatic juice to the small intestine, the pancreas breaks down carbohydrates, proteins, and lipids. Traditional Chinese medicine views the pancreas as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.

The pancreas plays a major role in regulating blood glucose levels by producing insulin.
Type 1 diabetes occurs when the pancreas does not make enough or any insulin. Type 2 diabetes develops when the body cannot use insulin correctly.

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even diagnosed early is very low compared to other types of cancer. The 5-year survival rate at stage IA pancreatic cancer is only14%.

The most common risk factors of pancreatic cancer are similar to those of common cancers, including age, family history, gender, ethnicity, smoking, being overweight or obesity and certain medical conditions such as diabetes.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find natural food in the prevention and treatment of tumors, researchers investigated the anticancer effects of kimchi prepared by the standard Baechu cabbage and Amtak Baechu cabbage.

4 different kimchi samples that were prepared for this study: (1) the standard Baechu cabbage and dry salt treatment method (SK-D); (2) the Amtak Baechu cabbage and dry salt treatment method (AK-D); (3) the standard Baechu cabbage and brine solution treatment method (SK-B); and (4) the Amtak Baechu cabbage and brine solution treatment method (AK-B).

In human pancreas cancer cells (Capan-2) and human liver cancer cells (HepG2), both cancer cells exposed to AK-D and AK-B showed a significant increase in cell growth inhibition, compared yo SK-D and SK-B (p < 0.05).

At 2.0 mg/mL, the inhibition of Capan-2 cells was more than doubled after treatment with AK-B and AK-D compared with SK-B and SK-D, but was only 1.2 times in HepG2 cells.

AK-D and AK-B treatment exhibited apoptosis and cell cycle arrest by a significant increase of p21 levels associated with cell cycle regulation.

AK-B exerted a higher cytotoxic activity compared with AK-D and the anticancer effects were more apparent in Capan-2 cells than in the HepG2 cells.

Based on the results, researchers wrote, "...kimchi made with Amtak Baechu cabbage and treated with brine solution (AK-B) had a superior anticancer potential against both types of cancer cells, with the effects being greater in pancreatic cancer cells compared with liver cancer cells".

Taken altogether, kimchi made with Amtak Baechu cabbage may be used for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beneficial Outcomes of Kimchi Prepared with Amtak Baechu Cabbage and Salting in Brine Solution: Anticancer Effects in Pancreatic and Hepatic Cancer Cells by Song GH1, Park ES1, Lee SM1, Park DB2, Park KY. (PubMed)

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