Fibrosis is a medical condition caused by the excessive formation of fibrous connective tissue in an organ or tissue.
Myocardial fibrosis is a medical condition caused by increased myofibroblast activity and excessive extracellular matrix deposition in the heart.
Myocardial fibrosis has been found to induce heart remodeling that leads to heart failure and death.
The severity of the grades range from A0 to A3:
A0: no activity
A1: mild activity
A2: moderate activity
A3: severe activity
and
The severity of fibrosis stages range from F0 to F4:
F0: no fibrosis
F1: portal fibrosis without septa
F2: portal fibrosis with few septa
F3: numerous septa without cirrhosis
F4: cirrhosis, the most severe stage of fibrosis
The most common causes of myocardial fibrosis are coronary heart disease, aortic stenosis, and hypertension.
Aortic stenosis and hypertension also have been found to pressure overload of the left ventricle induced hypertrophy and interstitial fibrosis.
* RAS-RH treatment mitigated these morphological injuries.
* RAS-RH also induced the apoptosis of primary rat cardiac fibroblasts after X- irradiation.
* Genes associated with the cellular proliferation of rat cardiac fibroblasts induced by TBI were all inhibited by the injection of RAS-RH.
Collectively, researchers said, "RAS-RH may potentially be developed as a medical countermeasure for the mitigation of radiation-induced myocardial fibrosis".
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of Radix Angelica Sinensis and Radix Hedysari ultrafiltration extract on X-irradiation-induced myocardial fibrosis in rats by Ma C1, Fu Z2, Guo H3, Wei H2, Zhao X2,
Li Y. (PubMed)
A0: no activity
A1: mild activity
A2: moderate activity
A3: severe activity
and
The severity of fibrosis stages range from F0 to F4:
F0: no fibrosis
F1: portal fibrosis without septa
F2: portal fibrosis with few septa
F3: numerous septa without cirrhosis
F4: cirrhosis, the most severe stage of fibrosis
The most common symptoms of are myocardial fibrosis are increased myocardial stiffness, cardiomyocyte necrosis, arrhythmias, sudden cardiac death, and unfavorable prognosis.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a natural compound for the treatment of diseases associated with fibrosis, the researchers examined the effects of Radix Angelica Sinensis and Radix Hedysari ultrafiltration extract (RAS-RH) on cardiac fibrosis induced by a single dose of total body irradiation (TBI) at 8 Gy.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a natural compound for the treatment of diseases associated with fibrosis, the researchers examined the effects of Radix Angelica Sinensis and Radix Hedysari ultrafiltration extract (RAS-RH) on cardiac fibrosis induced by a single dose of total body irradiation (TBI) at 8 Gy.
Based on the analysis,
* The control hearts exhibited less collagen and fibrosis compared to (TBI) treatment rats showed the increase in the serum levels of transforming growth factor β1 (TGF-β1) involved in cytokine expression and troponin-I (TnI) associated with the inhibition of blood vessel contraction.* RAS-RH treatment mitigated these morphological injuries.
* RAS-RH also induced the apoptosis of primary rat cardiac fibroblasts after X- irradiation.
* Genes associated with the cellular proliferation of rat cardiac fibroblasts induced by TBI were all inhibited by the injection of RAS-RH.
Collectively, researchers said, "RAS-RH may potentially be developed as a medical countermeasure for the mitigation of radiation-induced myocardial fibrosis".
Taken altogether, Herbal Angelica used in a combination with other herbal medicines may be considered a decoction for the prevention of myocardial fibrosis, pending to larger sample size and multicenter human study.
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of Radix Angelica Sinensis and Radix Hedysari ultrafiltration extract on X-irradiation-induced myocardial fibrosis in rats by Ma C1, Fu Z2, Guo H3, Wei H2, Zhao X2,
Li Y. (PubMed)
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