Thursday 3 September 2020

Angelica sinensis Processes a Potential Anti-Leukemia Activity

By Kyle J. Norton

Leukemia is a medical condition associated with an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow is the soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, leg. etc.

Bone marrow is a spongy substance found in the center of the bones with a function of manufacture the bone marrow stem cells and other substances, that produce blood cells.

There are several forms of leukemia, including acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myelogenous leukemia (CML).

CLL and AML are the most common cancers in adults and ALL are most common in children.

In contrast to chronic leukemias that take months or years to develop, acute leukemias start and develop within days or weeks.

According to Leukemia Research, Leukemia causes the death of approximately 68,000 every year. Adults are 10 times more likely to develop the disease, compared to children.

And, Non-Hodgkin's lymphoma is the 7th most common cancer in the U.S. The 5-year survival rate for all subtypes of leukemia is 61.4 percent.

Acute leukemia is a condition caused by a rapid increase in the numbers of extreme immature white blood cells which appear in the bloodstream into other parts of the body, including tissue and organs, including acute lymphoblastic leukemia (ALL), acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML).

In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia with about 80% of all cases.

Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells. The condition has a tendency to spread slowly to other parts of the body through the bloodstream and/or lymphatic system, including chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural ingredient for the prevention and treatment of cancer, scientists examined the new water-soluble polysaccharide, APS-1II, with a molecular weight of 42.1 kDa isolated from the roots of Angelica sinensis (Oliv.) anti-leukemia activity.

According to the experimental results,
* APS-1II inhibited the proliferation of human leukemia K562 and mouse L1210 cells in vitro and markedly prolonged the life span of L1210-bearing mice in vivo.

* APS-1II also increased the numbers of leukocytes and lymphocytes in peripheral blood and significantly decreased plasma tumor necrosis factor, interleukin-2, and interferon-γ levels in L1210-bearing mice.

* Moreover, APS-1II administration concentration-dependently promoted the proliferation of the splenocytes, enhanced phagocytic activity of peritoneal macrophages, and cytotoxicity of natural killer cells.

Based on the results, researchers suggest, "APS-1II could effectively inhibit leukemia and induce a protective immune response, and it may be used as a suitable candidate reagent for leukemia therapy".


Taken altogether, angelica sinensis may be considered an antioxidant remedy for the prevention and treatment of leukemia, pending to the confirmation of the larger sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Structure characterization and anti-leukemia activity of a novel polysaccharide from Angelica. (PubMed)

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