Broccoli's Sulforaphane Supplementation Has No Effects on Neutrophilic Airway Inflammation

By Kyle J. Norton

Respiratory Disease is medical conditions, that affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc.


Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.

Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nerves system, the immune first line of defense stimulates the production of blood platelets to the cover the site of damage and pro-inflammatory to kill off pathogens that try to enter the body through the wound or damaged tissue.

Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.

The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. 

The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centers in 56 countries.

Neutrophilic airway inflammation in asthma is a complication associated with the whole spectrum of asthma severity, ranging from mild-to-moderate to severe uncontrolled disease, compared to neutrophilic inflammation that occurs mostly in more severe asthma.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that protects the lung activity, researchers examined the effects of sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables on neutrophilic airway inflammation.

The study included male rats that were divided into the control group fed the AIN-76 diet, and the BSEx group fed the AIN-76 diet containing BSEx for 10-days.

On airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2), supplementation of SFN with broccoli sprout homogenate did not induce the expression of antioxidant genes in healthy human subjects.

In an ozone-exposure model, the supplementation showed no effects in the protection against neutrophilic airway inflammation.

In other words, dietary sulforaphane supplementation did not promote the production of antioxidant enzymes in the tested model through its anti-inflammatory activity

Based on the finding, researchers said, "supplementation of SFN with broccoli sprout homogenate is not a promising candidate for large-scale clinical trials targeting airway inflammation".

Taken altogether,  broccoli may be considered liver detoxed functional food, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation by Duran CG1, Burbank AJ1, Mills KH1, Duckworth HR1, Aleman MM1, Kesic MJ2, Peden DB1, Pan Y3, Zhou H3, Hernandez ML. (PubMed)