Saturday, 8 August 2020

Omega 3 Fatty Acids, A promising Anti Chronic Cerebral Hypoperfusion Remedy

By Kyle J. Norton

Chronic cerebral hypoperfusion is a medical condition associated with the small vessel diseases or atherosclerosis of multiple large vessels found mostly in people who are cognitive normal elderly and patients who have cognitive impairment.

Acute cerebral hypoperfusion has been found to induce neuronal necrosis and infarction, compared to chronic cerebral hypoperfusion that causes the apoptosis of neurons.

A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role to process and transmit information.

The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.

*The motor neurons transmit impulses from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.

* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.

Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role to process and transmit information.

Cerebrovascular disease is a common cause of Alzheimer's disease (AD).

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential plant that processes neuroprotective activity researchers examined the effect of gamma-linolenic acid in the rat brain tissues after bilateral common carotid artery occlusion (BCCAO) rat model of chronic cerebral hypoperfusion.

According to the results of the analysis,
* Arachidonic acid (ARA), docosahexaenoic acid (DHA), dihomo-γ-linolenic acid, hydroxyeicosatetraenoic (HETE)-Ala and glycerophosphoethanolamine levels were significantly reduced in the hippocampus and cortex of animals submitted to BCCAO model when compared to control animals.

* Decanoic acid was increased after 30 days of BCCAO model.

Collectively, researchers said, "these findings indicate that lipid dynamics are altered in chronic ischemia-induced by BCCAO in rats and indicate potential biomarkers and pharmacological targets for vascular dementia (VD)".

Taken altogether, omega3 fatty acids may be considered a remedy for the prevention and treatment of chronic cerebral hypoperfusion,, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cerebral Lipid Dynamics in Chronic Cerebral Hypoperfusion Model by DESI-MS Imaging by
Severiano DLR1, Oliveira-Lima OC1, Vasconcelos GA2, Lemes Marques B1, Almeida de Carvalho G1, Freitas EMM1, Xavier CH3, Gomez MV4, Pinheiro ACO5, Gomez RS6, Vaz BG7, Pinto MCX8. (PubMed)

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