Dandelion(Taraxacum officinale) inhibits the Onset of Liver Toxicity in Vivo

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

Liver disease is a class of medical conditions characterized by the reducing partly or completely the function of the liver, including liver failure.

Liver toxicity is a condition caused by the accumulation of toxin in the liver, leading to liver dysfunction or reduced liver function.

Acute liver toxicity is caused by short-term exposure to toxic chemicals such as an overdose of medication.

Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long term use of certain medicines.

In other words, if the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.

Epidemiological studies suggested liver dysfunction can also induce acute kidney injury (AKI), chronic kidney disease, linking to the increased mortality, and extending to those with chronic liver disease.

The most common signs and symptoms of liver toxicity may include jaundice, abdominal pain, gastrointestinal discomforts, fatigue, Stomach pain. Nausea (upset stomach) Unusual tiredness. dark-colored urine, and pale-colored bowel movements.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the promotion of liver functioning, scientists examined the hepatic toxic effects of prenatal exposure to lead in rats by adding the dandelion (Taraxacum officinale) to the diet.

Selected female rats induced liver toxicity by lead acetate was administered to half of the rats through drinking water from the 5th day of gestation until the 14th day postpartum accompanied by a normal diet (control) or a diet enriched with dandelion (treated) throughout the study for 14 days.

Control female rats fed with lead acetate showed a lead deposition in the blood and stomach of their pups as well as hepatic tissue damages.

Moreover, female tested rats fed with lead acetate also significant decreases in liver weight and protein content

Additionally, the lead treatment caused an increase in the levels of oxidative stress and stress markers by reducing the activity of antioxidant enzymes.

However, rats co-treated with lead and dandelion showed no damages or biochemical changes in puppies and mothers.

In other words, the dandelion extract inhibited the poisoning activity in the induction of liver oxidative stress and liver toxicity.

Collectively, researchers wrote, "supplementation of pregnant and lactating rats with dandelion protects their offspring against lead poisoning, likely through reduction of oxidative stress and liver damages".

Taken altogether, Dandelion may be considered a remedy for the protection of liver against chemical toxicity, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dandelion-enriched diet of mothers alleviates lead-induced damages in liver of newborn rats by Gargouri M1, Magné C2, Ben Amara I3, Ben Saad H4, El Feki A. (PubMed)