Herbal Angelica in the Promotion of Strong Bones

By Kyle J. Norton

Bone is a hard whitish tissue making up the skeleton in humans which provides a framework for the attachment of muscles and other tissues.

Bone density is the amount of bone mineral in bone tissue. Loss of bone density is found to induce osteoporosis.

Bone density is measured by the young adult bone density mean within 1 standard deviation (+1 or −1). The negative T-score is an indication of loss or lower bone density and the T-score of −2.5 or lower is an indication of osteoporosis.

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

The condition is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries.

The exact causes of osteoporosis are unknown. Neither researchers understood that people with the same health conditions are affected by the imbalance between new bone formation and bone resorption while others do not.

However, researchers do know that certain risk factors such as a lid to increase lifelong calcium-deficient diet, age, female, family history,.... bone structure and overweight are associated with the early onset of osteoporosis.

Furthermore, long-term intake of certain medications such as prednisone and a medical condition such as rheumatoid arthritis are also the osteoporosis prevalent risk factors

According to the statistic, 1 in 3 women and 1 in 5 men older than 50 will suffer from an osteoporosis fracture, worldwide.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential herbal medicine for the prevention and treatment of osteoporosis, researchers examined the Angelicapolysaccharide (AP), the main component of angelica on mesenchymal stem cell (MSC) proliferation and osteoblast differentiation.

According to the results of MSCs treated with different concentrations of AP, AP significantly promoted cell viability, upregulated cyclin D1 associated with progression through the G1 phase of the cell cycle. and increased RUNX2, OCN, ALP, and BMP-2 protein levels involved in osteoblast differentiation in MSCs.

Additionally, AP notably activated PI3K/AKT and Wnt/β-catenin signaling pathways that maintain the integrity of bone mass maintenance by regulating the activity of the bone-forming osteoblasts in MSCs.

Moreover, the administration of AP also upregulated the relative expression level of H19 which has been found to induce osteogenesis and promote trabecular bone growth in a dose-dependent manner.

In other words, the mesenchymal stem cell (MSC) analysis suggested that AP protects bone density by increasing the bone cell formation.

More importantly, in vivo experimentation, the results also indicated a further confirmation of the promoting effect of AP on bone formation.

Taken altogether, Herbal Angelica may be considered a remedy for the protection of bone density, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica polysaccharide promotes proliferation and osteoblast differentiation of mesenchymal stem cells by regulation of long non-coding RNA H19: An animal study by Xie X1, Liu M2, Meng Q. (PubMed)