Wednesday, 12 August 2020

Herbal Dandelion(Taraxacum officinale) Inhibits Fatigue and Modulates the immunological parameters

By Kyle J. Norton

The immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens, including bacteria, viruses, parasites, etc. and tumor cells, including irregular cells growth, cancer cells to keep us healthy. 

In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.

However,  during the process of their functions, they may induce the production of free radicals and a chain of free radicals that can be harmful to our bodies.

The immune system has 2 functional divisions: the innate and the acquired. Both involve various blood-borne factors and cells.

Many immunological parameters, including genetics, gender, age, nutrient status, and gut flora have been found to affect the immune responses.

People with a significantly below "normal" immune function are more susceptible to infectious agents and exhibit increased infectious morbidity and mortality.

Fatigue is the condition of feeling very tired, weary or sleepy. Most cases of fatigue are a result of insufficient sleep, prolonged mental or physical work, or extended periods of stress or anxiety. 

However, people who carry repetitive tasks can intensify feelings of fatigue. 

Fatigue can be described as either acute or chronic.

Unlike acute fatigue that can be recovered in a short time, chronic fatigue syndrome (CFS) is a medical disorder which cannot be explained by an underlying medical condition, characterized by persistently extreme fatigue that never goes away regardless of treatment.for at least 6 months.

The exact causes of chronic fatigue syndrome are unknown. 


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient that improves energy levels and health. scientists examined the anti-fatigue and immune-enhancing effects of dandelion (TO) in mice by performing a forced swimming test (FST) and in vitro by using peritoneal macrophages.

The mice induced fatigue given daily oral administration of TO (100 mg/kg), were found to decrease fatigue, FST immobility time on the tenth day.

Furthermore, TO (10 and 100 mg/kg) treatment significantly increased glucose levels, acting as an energy source and decreased muscle damage.

Moreover, TO (100 mg/kg) orally administered to mice also decreased the blood urea nitrogen levels significantly.

Additionally, in vitro by using peritoneal macrophages, TO treatment showed a significant increase of the production of NO through inducible nitric oxide synthase (iNOS) induction involved in pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-12p70, and IL-10.

Taken altogether, Dandelion may be considered a remedy for the treatment of fatigue and immunological parameters, pending to the confirmation of the larger sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Taraxacum officinale on fatigue and immunological parameters in mice by Lee BR1, Lee JH, An HJ. (PubMed)

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