Herbal Angelica Promotes the Immunomodulatory Activity

By Kyle J. Norton

The immune system is the set of cells that comprise the body's defense system against diseases against antigens or infectious agents

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

The overactive immune system is a class of autoimmune diseases or chronic inflammatory diseases caused by the immune system attacking the body's tissue, including rheumatoid arthritis (RA), rheumatoid arthritis, systemic lupus erythematosus,.... and multiple sclerosis.

The widespread chronic inflammatory diseases in modern society are a burden to humans because of life-long debilitating illness, increased mortality and high costs for therapy and care.

On the other hand, an underactive or weakened immune system caused by a primary immune deficiency or acquired immune deficiency.may not protect the body against foreign organisms in initiated infection. 

Primary immune deficiency is an underactive immune system that is caused by genetic mutation inherited from parents.

Acquired immune deficiency is a weakened immune system caused by diseases that destroy white blood cells.

In other words, the immunomodulatory activity involved antimicrobial agents is to modulate the genes involved in immune reactions, or of the neurohormonal system which regulates immune functions and any toxic or immunotoxic effects such as allergic reactions or destruction of immune effectors, that may cause harm to the body or interfere with the body normal function.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential herbal medicine to improve the immune functioning, researchers examined the immunomodulatory activity of four fractions of angelica (Angelica polysaccharide, oligosaccharides (Angelica oligosaccharide and Angelica sucrose) and Angelica total amino acid, named APS, AOS, AS, and TAA on murine peritoneal macrophages.

Based on the results of the analysis, Although APS exhibited the most obvious growth facilitative activity, AOS did better in the activation of H(2)O(2) release.

TAA exerted the best activation of phagocytic activity, production of NO and ICAM-1 expression.

Furthermore, the action mode of the four fractions was similar to that of LPS and the mechanism may be related to the upregulation of TLR4 mRNA. in the regulation of the immune response.

These results demonstrated that all 4 tested fractions isolated from the Radix A. Sinensis, could serve as an immunomodulator for the improvement of the immune functioning.

Taken altogether, Herbal Angelica processes immunomodulatory activity, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Assessment and comparison of immunoregulatory activity of four hydrosoluble fractions of Angelica sinensisin vitro on the peritoneal macrophages in ICR mice by Chen Y1, Duan JA, Qian D, Guo J, Song B, Yang M. (PubMed)