Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.
Most cases of primary pancreatic cancer start in the cell on the surface of the inner lining of the pancreatic tissue, before penetrating into the deeper layers to form a large and invasive tumor.
At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.
According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.
The survival rate of pancreatic cancer even diagnosed at a very early stage is very low compared to other types of cancer. The 5-year survival rate at stage IA pancreatic cancer is only14%.
At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.
According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.
The survival rate of pancreatic cancer even diagnosed at a very early stage is very low compared to other types of cancer. The 5-year survival rate at stage IA pancreatic cancer is only14%.
Other prevalent risk factors, including long-term use of tobacco, exposure to certain chemicals, overweight, and obesity, and unpreventable risk factors of family history, gender, the increase of age and ethnicity are associated with the early onset of pancreatic cancer.
The secondary pancreas cancer has been found to be a metastasis from renal cell cancer, lung, colon and breast cancers.
Moreover, miR30a-3p-overexpressing tumor xenografts had decreased tumor volume and increased gemcitabine sensitivity in pancreatic cell lines.
The study included 16 subjects randomized, into 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.
In patient tissues, a higher expression of miR30a-3p and a lower expression of Cx43 correlated with malignancy.
Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of sulforaphane (SF) on the pancreatic cancer cell lines.
In established cell lines and a patient tissue array (n = 96), sulforaphane inhibited the expression of miR30a-3p in the induction of cancer cell lines.
On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of sulforaphane (SF) on the pancreatic cancer cell lines.
In established cell lines and a patient tissue array (n = 96), sulforaphane inhibited the expression of miR30a-3p in the induction of cancer cell lines.
Furthermore, miR30a-3p mimics inhibited the luciferase activity of a Cx43 3'-UTR, a tumor suppression.
In patient tissues, a higher expression of miR30a-3p and a lower expression of Cx43 correlated with malignancy.
Based on the evidence, researchers said, "These findings provide new knowledge and suggest sulforaphane as cotreatment for pancreatic cancer".
Taken altogether, the consequences of these results suggest that the broccoli process the potential anti-pancreatic activity, pending to the confirmation of the larger sample size and multicenter human study.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer by Georgikou C1, Yin L2, Gladkich J3, Xiao X4, Sticht C5, Torre C6, Gretz N7, Gross W8, Schäfer M9, Karakhanova S10, Herr I. (PubMed)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer by Georgikou C1, Yin L2, Gladkich J3, Xiao X4, Sticht C5, Torre C6, Gretz N7, Gross W8, Schäfer M9, Karakhanova S10, Herr I. (PubMed)
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