Sunday, 4 November 2018

Phytochemical Piperine Cuts Off Energy Supply of Cancer Cells, Scientists Find

By Kyle J. Norton

Piperine, a phytochemical alkaloid in the class of organosulfur compound may have a significant effect in blocking the energy that is necessary for cancer cells proliferation and survival, some scientists suggested.

Angiogenesis is the formation of new blood vessels in the body for healing and reproduction.

However, in invasive cancers, the formation of a new blood vessel from pre-existing vessels stimulated by cancer chemicals may be deadly to the host.

These new blood vessels provide the nutrients and fluids for cancer growth and metastasis.

Cancer is a class of diseases, characterized by cell growth irregularly that starts in the surface of the inner lining of tissue or organs. Patients at the beginning of cancer onset do not experience any symptom.

At the later stage of the progression, the cancerous cell may travel a distance away from the primary site to infect other healthy tissue and organs. If cancer has grown large enough, it may affect other nearby healthy tissue and nerve cells, causing localized symptoms and persistently severe pain.

Angiogenesis occurred are totally depending on a net balance of angiogenic factors and antiangiogenic factors, which are secreted by both tumor cells and host-infiltrating cells. If the tumors angiogenic factors win, the new blood vessels are formed.

Some researchers suggested if we can produce a drug that cuts of the forming of the new blood vessel which supplies energy to cancer, we may cure cancer. 

However, according to the epidemiological studies, antiangiogenic therapy in the inhibition of the growth of the tumor works best in combination with conventional cytotoxic chemotherapy.

Dr. Roberta WC Pang, the lead author in the investigation "Clinical Implications of Angiogenesis in Cancers" wrote, "Recently, a monoclonal antibody against vascular endothelial growth factor, which is one of the most potent angiogenic factors, has been approved for clinical use in colorectal cancer patients after a clinical trial confirmed that combining the antibody with standard chemotherapy regimen could prolong patient survival".

We can only hope that in a distant future, a single miracle drug can have an antiangiogenic potency to block off all cancers proliferation.

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.

A research team at the Dalhousie University in the investigation of piperine, a major alkaloid constituent of black pepper physiological actions in inhibition of cancer cells proliferation including the killing of cancer cells launched a study to examine the angiogenetic effect of piperine in tumor progression.

Injection of piperine inhibited the proliferation and G(1)/S transition of human umbilical vein endothelial cells (HUVECs) without causing cell death.  

In vitro, piperine also inhibited HUVEC migration and tubule formation and collagen-induced angiogenic activity in rat aorta explants and breast cancer cell-induced angiogenesis in chick embryos.

Importantly, piperine inhibited phosphorylation of Ser 473 and Thr 308 residues of Akt (protein kinase B), which is a key regulator in the induction of cancer cells survival and angiogenetic proliferation.

The findings reconfirmed the function of piperine as an angiogenesis inhibitor for use in cancer treatment.

Additionally, in the finding of the phytochemical which processes a strong effect in improving the function of curcumin,  in the suppression of angiogenesis by inhibiting the curcumin lack of water solubility, and relatively low bioavailability.

After multiple approaches are being sought to overcome these limitations, researchers finally discovered natural curcumin analogs, namely piperine.

 Piperine in the co-administration with curcumin enhanced the functions of curcumin in the suppression of angiogenesis without reducing the antitumor activity.

Taken altogether, piperine may be considered a functional supplement used for the prevention of cancers and an adjunction therapy by cutting the supply of energy of cancer that is life and death for cancer colonization, depending to the further study of a large sample size and multi-center in human consumption.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Piperine, a dietary phytochemical, inhibits angiogenesis by Doucette CD, Hilchie AL, Liwski R, Hoskin DW.(PubMed)
(3) Clinical Implications of Angiogenesis in Cancers by Roberta WC Pang1 and Ronnie TP Poon. (PMC)

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