Wednesday, 21 November 2018

Honey, the Potential Anti-Colon Cancer Functional Food

By Kyle J. Norton

Scientists may have found a sweet functional food that processes a potential for the prevention and treatment of cancer, some studies suggested.

Cancers are the group of chronic diseases, caused by cell growth disorderly and uncontrollably in some specific tissue and organs.

Most primary cancers start in the cells on the surface of the inner lining of a tissue caused the alternation of DNA.

At the later stage, after penetrating deep in the tissue of the infected organs, most primary cancer can travel a distance away from the original site to damage other healthy tissue and organs.

As they grow large enough, they can also suppress the nearby tissue and nerve cells, causing severe pain and localized symptoms.

Researchers do not know the exact causes of colon cancer. Neither they know why some people with the same health conditions, diet pattern and ethnicity and family history, some are susceptible to the early onset of the diseases, while many others do not.

Most common risk factors, epidemiologically are associated with the types of cancer. The National Cancer Institute suggested that aging, tobacco, long-term sun and radiation exposure, chemicals and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight are the common causes of cancer.

In the challenges, the idea that cancer cannot be prevented among older adults, researchers at the National Center for Chronic Disease Prevention and Health Promotion launched a study by examining different aspects of the relationship between age and cancer said, "Although the sequential patterns of aging cannot be changed, several age-related factors that contribute to disease risk can be".

What are the age-related factors that contribute to cancer be changed? researchers continued. "For most adults, age is coincidentally associated with preventable chronic conditions, avoidable exposures, and modifiable risk behaviors that are causally associated with cancer", and "current evidence suggests that for most adults, cancer does not have to be an inevitable consequence of growing older. Interventions that support healthy environments, help people manage chronic conditions, and promote healthy behaviors may help people make a healthier transition from midlife to older age and reduce the likelihood of developing cancer:

These results furtherly emphasized the needs to prevent chronic diseases and support a healthy environment and promote a healthy lifestyle in the transition from midlife to the older age are most important factors that can reduce substantially the risk of cancer.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launch an investigation to examine the anti-tumor and anti-inflammation properties of crude ginger extract and Gelam honey against many types of cancer, including colorectal cancer.

The cells used in the experiment were divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined.

Combined ginger and Gelam honey treatment stimulated the early cell death response through enhancing the function of proteins associated with programming cell death, namely, the caspase 9 and IκB genes and inhibiting the function of proteins associated with cells proliferation.

The IC50 of ginger and Gelam honey alone were 5.2 mg/ml and 80 mg/ml, respectively also demonstrated a similar efficacy as of the IC50 of the combination treatment of 3 mg/ml of ginger plus 27 mg/ml of Gelam honey.

These results suggest ginger and Gelam honey used alone or combination may be an effective chemopreventive and therapeutic strategy for inducing the death of colon cancer cells.

Further differentiation of the anti-proliferative effects of ginger and Gelam honey and their efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that
* Ginger (IC50 of 3mg/mL) is more potent than the Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.

* Combined treatment (35 mg/mL) of the two compounds (3mg/mL ginger+75 mg/mL Gelam honey) synergistically lowered the IC50 of Gelam honey to 22 mg/mL without reducing the inhibitory effect against colon cancer cell line.

* Gelam honey markedly enhanced 5-FU inhibiting effects on the growth of HCT 116 cells.

Subsequent analysis on the induction of cellular apoptosis also suggested the individual treatment of ginger and Gelam honey produced higher apoptosis compared to 5-FU alone.

These results once against suggested that Gelam honey and ginger extract used alone or combination could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.

Taken altogether, honey used alone or combined with ginger might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-cancer possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anticancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(4) Age and Cancer Risk by A Potentially Modifiable Relationship
Mary C. White, ScD, Dawn M. Holman, MPH, Jennifer E. Boehm, MPH, Lucy A. Peipins, PhD, Melissa Grossman, MPH, and S. Jane Henley, MSPH. (PMC)

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