Tuesday, 6 November 2018

Hawthorn Fruit, the Herbal Remedy Which May Process Anti Non Alcoholic Fatty Liver Disease (NAFLD) Potency

By Kyle J Norton, Master of Nutrition

Scientists may have discovered a potent natural ingredient for the prevention and treatment of Nonalcoholic Fatty liver disease (NAFLD) without inducing any side effects, some studies suggested.

Non-alcoholic fatty liver disease is a condition characterized by excessive fat the accumulation in the liver, other than abusive alcohol drinking.

Patients with non-alcoholic fatty liver disease in the early stage may not experience any symptoms, however, at the later stage, due to the formation of liver scars in the liver, the disease may decrease the liver function in detoxifying harmful substances, cleaning the blood and making vital nutrients to the body needs.

Patients in this stage may also experience symptoms of persistent fatigue, bleeding and bruising easily, itchy skin and yellow discoloration in the skin and eyes and persistent fluid accumulation in your abdomen.

Some researchers suggested that the prevalence of non-alcoholic fatty liver disease over a few decades is correlated to the widespread of obesity due to abnormalities in fatty acid metabolism, in conjunction with adipose tissue, hepatic, and systemic inflammation.

Dr. Lu FB, the lead author in the study, " The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis", said, "obesity may not be an independent factor for the development of NASH or advanced fibrosis in NAFLD patients and NAFLD should be considered as potential population for pharmacologic treatment regardless of obesity. In addition, PNPLA3 rs738409 may be more relevant to the progression of non-obese NAFLD when compared to obese NAFLD".

The rs738409 polymorphism of the PNPLA3 gene is associated with the onset of hepatic steatosis and fibrosis.

Starvation and protein malnutrition, long-term use of total parenteral nutrition, intestinal bypass surgery for obesity, rapid weight loss and medical conditions such as hyperlipidemia (elevated lipids in the blood), insulin resistance and high blood pressure. genetic preposition and long-term use of medication are also the prevalent risk factors of the disease onset.

Hawthorn is shrubs and trees of the genus Crataegus, belonging to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia, and North America.

The herb has been used in traditional medicine to treat heart disease and symptoms of heart diseases such as irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, etc., circulatory disorders and respiratory illnesses.

 Researchers at The First Affiliated Hospital of Wenzhou Medical College, in the concerns that nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition worldwide, and reaffirm the natural treatments of nonalcoholic fatty liver disease (NAFLD) launched an investigation to find natural medicines for the treatment of NAFLD without prominent side effects.

Truly, alternative medicines for the treatment of NAFLD have been proven with many successful histories of controlling the disease with no or fewer side effects, compared to conventional treatment of the same

The search of the database of PubMed and China National Knowledge Infrastructure from January 1995 to June 2010 for RCTs comparing either traditional Chinese medicine (TCM) formulations alone or in combination with placebo, ursodeoxycholic acid, insulin sensitizers, lipid-lowering drugs, or antioxidants found 5904 patients from 62 RCTs and 25,661 patients from 419 clinical studies with TCM formulation analysis.

In the compared studies, TCM had a better effect on the normalization of alanine aminotransferase and disappearance of radiological steatosis in the treatment of NAFLD, compared to Western medicine without inducing any side effects.

In general,  Chinese herbal formulas have found to be effective, compared to the single herb in reducing the abnormality of fat accumulation in the liver.

Researchers after counting numbers of herbs used in the studies, out of 246 kinds of Chinese herbs included in our present study, with an average of 10 herbs (range 1-31) in each formulation, Hawthorn fruit was the most often used herb in the treatment of NAFLD.

Dr. the lead author, after taking into account co and confounders said, " TCM is of modest benefit to the treatment of NAFLD".

Taken altogether, Hawthorn Fruit may be considered a functional food used combination with other herbal medicine for the prevention and treatment of nonalcoholic fatty liver disease (NAFLD), depending on the further data collection of large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compound during the course of the disease will be necessary to complete the picture of Hawthorn fruit anti- NAFLD possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH. (PubMed)
(2) The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis by Lu FB1, Hu ED1, Xu LM1, Chen L1, Wu JL1, Li H1, Chen DZ2, Chen YP. (PubMed)

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