Tuesday, 12 April 2016

Most Common Disease of 50 Plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Gout: The Symptoms

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                                                  The Symptoms

In the study carry out a cross-sectional survey on prevalence of musculoskeletal symptoms, rheumatoid arthritis (RA), ankylosing spondylitis (AS), and gout, Dr. Dai SM, and the research team at the Second Military Medical University, in the interviewe a total of 6584 adults (3394 women, 3190 men) with the response rate of 86.6%. showed that symptoms occurred more frequently in the following sites: knee 7.0% (95% CI 6.4-7.6%), lower back 5.6% (95% CI 5.0-6.2%), shoulder 4.7% (95% CI 4.2-5.2%), and neck 2.4% (95% CI 2.0-2.8%). Women complained of rheumatic symptoms more frequently than men. The standardized rates of RA, AS, gout, symptomaticknee osteoarthritis, and soft tissue rheumatism were 0.28% (95% CI 0.15-0.41%), 0.11% (95% CI 0.03-0.19%), 0.22% (95% CI 0.11-0.33%), 4.1% (95% CI 3.6-4.6%), and 3.4% (95% CI 3.0-3.8%), respectively(1a).
Most frequent symptoms of gout as a result of tophus(4), according to studies including
1. Warmth(1), pain(1), particular endpoint pain(2), swelling(1), erythema(1), and extreme tenderness(2)(called podagra. when it effects the big toe), according to the Cadence Physician Group/Orthopaedics(1)
2. Very red or purplish skin on the affect joint(5)
3. Reduced movement of affect joint and big toe, according ot the study by the Auckland University of Technology, walking shoes with good footwear characteristics can influence plantar pressure values and encourage a more efficient heel to toe gait pattern in people with gout(3).
4. Induced skin itching and peeling when the affect joint begins to heal(5)
5. Intractable back pain and fever if it a  spinal gout(6).

In fact, symptoms are quite noticeable, you may feel well when you go to bed but wake up during the night with intense pain in one or few joints and sometime with fever. The symptoms may go away in a few days, but can return from time to time. Chronic gout can cause lumps(4) below the skin around the affect areas.

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(*) Musculoskeletal disorders and disability in persons aged 85 and over: a community survey. by van Schaardenburg D1, Van den Brande KJ, Ligthart GJ, Breedveld FC, Hazes JM.(PubMed)
(1) Diagnosis and management of gout in total knee arthroplasty by Buck M1, Delaney M.(PubMed)
(2) Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator by Terkeltaub RA, Schumacher HR, Carter JD, Baraf HS, Evans RR, Wang J, King-Davis S, Weinstein SP.(PubMed)
(3) The effect of good and poor walking shoe characteristics on plantar pressure and gait in people with gout by Stewart S1, Dalbeth N2, McNair P3, Parmar P4, Gow P5, Rome K3.(PubMed)
(4) Tophi as first clinical sign of gout by Thissen CA1, Frank J, Lucker GP.(PubMed)
(5) Symptoms of gout(NHS choice)
(6) [Fever and back pain--a case report of spinal gout].[Article in German] by Schorn C1, Behr C, Schwarting A.(PubMed)