Tuesday, 26 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Garlic

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

 The top anti inflammatory Foods

The top 5 anti inflammatory foods in reduced risk of over expression of pro inflammatory cytokine are always important to prevent the early onset and patient with gout as well as the expression of cardiovascular and renal risks(190).
2.1. Garlic 
Inflammation plays an important roles in the early onset of uric acid involved the develop of gout. Dr. Perez-Ruiz F and Dr, Becker MA suggested, inflammation may provide a mechanistic explanation, related to some important chronic co-morbidities remains uncertain(189).
According to the joint study led by the Instituto de Neurobiología, alliin, a garlic (Allium sativum) compound inhibited the exprssion of LPS-induced inflammation(186) in 3T3-L1 adipocytes(187), involved decreasing serum levels of glucose, insulin, triglycerides, and uric acid, as well as insulin resistance, and cytokine levels(187).
Dr. Percival Ssaid, "Garlic contains numerous compounds that have the potential to influence immunity. Immune cells, especially innate immune cells, are responsible for the inflammation necessary to kill pathogens. Two innate lymphocytes, γδ-T and natural killer (NK) cells, appear to be susceptible to diet modification"(188).

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(186) Purified aged garlic extract modulates allergic airway inflammation in BALB/c mice by Zare A1, Farzaneh P, Pourpak Z, Zahedi F, Moin M, Shahabi S, Hassan ZM.(PubMed)
(187) Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes by Quintero-Fabián S1, Ortuño-Sahagún D2, Vázquez-Carrera M3, López-Roa RI4.(PubMed)
(188) Aged Garlic Extract Modifies Human Immunity by Percival SS1.(PubMed)
(189) Inflammation: a possible mechanism for a causative role of hyperuricemia/gout in cardiovascular disease by Perez-Ruiz F1, Becker MA2.(PubMed)
(190) Detrimental role of hyperuricemia on the cardio-reno-vascular system by Stack A1, Manolis AJ2, Ritz E3.(PubMed)

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