Thursday, 28 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Shiitake mushroom

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

The top anti inflammatory Foods

2.4. Shiitake mushroom
Shiitake mushroom is an edible mushroom, genus Lentinula, belongings to family Marasmiaceae, native to East Asia and widely cultivated for consumption for its health benefits and commercial purpose in many Asian countries. According to the joint study led by the University of Florida, intake of Shiitake mushroom improved immunity, through cell proliferation and activation and increased sIgA production, reduced inflammation via cytokine and serum CRP levels(200). Dr. Urano W and colleagues at the Tokyo Women's Medical University said, "Decrease in SUA during acute gouty arthritis is associated with increased urinary excretion of uric acid; an inflammatory process may play a role in the mechanism"(201).
The effect of Shiitake mushroom on Interleukin-6 (IL-6), a monokine with a number of biological activities, are intimately related to inflammatory responses in ameliorated serum uric acid (SUA) and increased uric acid excretion(201)(202).

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(200) Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults by Dai X1, Stanilka JM1, Rowe CA1, Esteves EA2, Nieves C Jr1, Spaiser SJ1, Christman MC3, Langkamp-Henken B1, Percival SS1.(PubMed)
(201) The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis by Urano W1, Yamanaka H, Tsutani H, Nakajima H, Matsuda Y, Taniguchi A, Hara M, Kamatani N.(PubMed)
(202) Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases by Swaak AJ1, van Rooyen A, Nieuwenhuis E, Aarden LA.(PubMed)