Wednesday, 27 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The top anti inflammatory Foods - Turmeric

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

The top anti inflammatory Foods

2.2. Turmeric
Turmeric with the similar property as garlic in enhancing immune system fighting against inflammation caused by either free radicals and foreign invasion(191). Recent study suggested, IL-1β inhibited by turmeric(195) is a potent proinflammatory cytokine of the innate immune system involved in host defense against infection. may increase production of IL-1β which plays a pathogenic role in various inflammatory diseases, such as rheumatoid arthritis, gout(194).
In animal with gout study, there was a positive correlation between intra-articular macrophage migration inhibitory factor involved in increased synovial fluid of patients with acute gout and IL-1β concentration(196).
According to the joint study led by the Federal University of Technology and China Pharmaceutical University, turmeric (Curcuma longa) exhibited effects on enzyme activities of purinergic and cholinergic systems as well as inflammatory cytokine levels(192). including including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)(192) through inhibiting the xanthine oxidase (XOD) activity related to amelioration of urinary uric acid (Uur) level(193).

(191) Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa)
by Chainani-Wu N1.(PubMed)
(192) Effect of Ginger and Turmeric Rhizomes on Inflammatory Cytokines Levels and Enzyme Activities of Cholinergic and Purinergic Systems in Hypertensive Rats by Akinyemi AJ1, Thomé GR2, Morsch VM2, Bottari NB2, Baldissarelli J2, de Oliveira LS2, Goularte JF3, Belló-Klein A3, Duarte T4, Duarte M4, Boligon AA5,Athayde ML5, Akindahunsi AA1, Oboh G1, Schetinger MR2.(PubMed)
(193) Study on the anti-gout activity of chlorogenic acid: improvement on hyperuricemia and gouty inflammation by Meng ZQ1, Tang ZH, Yan YX, Guo CR, Cao L, Ding G, Huang WZ, Wang ZZ, Wang KD, Xiao W, Yang ZL.(PubMed)
(194) Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release by Hecker A1, Küllmar M1, Wilker S1, Richter K2, Zakrzewicz A1, Atanasova S1, Mathes V1, Timm T3, Lerner S1, Klein J4, Kaufmann A5, Bauer S5, Padberg W1,Kummer W6, Janciauskiene S7, Fronius M8, Schweda EK9, Lochnit G3, Grau V10.(PubMed)
(195) Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse by Zhang N1, Li H1, Jia J2, He M3.(PubMed)
(196) Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1β production in a murine model of acute gout by Galvão I1, Dias AC1, Tavares LD2, Rodrigues IP1, Queiroz-Junior CM3, Costa VV2, Reis AC3, Ribeiro RD4, Louzada-Junior P4, Souza DG2, Leng L5, Bucala R5, Sousa LP6, Bozza MT7, Teixeira MM8, Amaral FA9.(PubMed)

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