Wednesday, 20 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Tophi

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                   The Complications
1. Tophi
Tophi is a forming of lumps building up around the joint due to chemical called uric acid. According to the University Hospital Southampton NHS Foundation Trust, tophi may be managed and treated by non-surgical and surgical procedures(102). 
Allopurinol, the conventional medication, allopurinol (100 to 600 mg daily) expressed low- to moderate-quality evidence indicating similar effects on withdrawals due to adverse events (AE) and serious adverse events (SAE). and incidence of acute gout attacks in randomised controlled trials (RCTs) or quasi-randomised controlled clinical trials (CCTs)(103). And benzbromarone is probably more successful than probenecid at achieving serum urate normalisation in people with gout(104).
According to the Hospital General Universitario de Alicante, diet supplements of vitamin C, has shown to the attenuated forming of lumps on joints but the study did not assess tophus regression, pain reduction or disability or health-related quality of life impact. The study reported no adverse events and no participant withdrawal due to adverse events(105).
Furthermore, there is good evidence from observational studies of an association between various lifestyle risk factors and gout development but the The Royal Melbourne Hospital, Parkville, Australia study did not include the expression of physical function, tophus regression and serum urate normalisation(106).

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(102) Interventions for tophi in gout by Sriranganathan MK1, Vinik O, Bombardier C, Edwards CJ.(PubMed)
(103) Allopurinol for chronic gout by Seth R1, Kydd AS, Buchbinder R, Bombardier C, Edwards CJ.(PubMed)
(104) Uricosuric medications for chronic gout by Kydd AS1, Seth R, Buchbinder R, Edwards CJ, Bombardier C.(PubMed)
(105) Dietary supplements for chronic gout by Andrés M1, Sivera F, Falzon L, Buchbinder R, Carmona L.(PubMed)
(106) Lifestyle interventions for chronic gout by Moi JH1, Sriranganathan MK, Edwards CJ, Buchbinder R.(PubMed)

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