Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Advanced gout

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

           
                                   The Complications

5. Advanced gout
Untreated gout may cause even more deposits of urate crystals to form under the skin in nodules called tophi (TOE-fie), leading to advanced gout with tophi developed in several areas, including fingers, hands, feet, elbows,.......Occasionally,untreated gout can lead to advanced arthritic changes. and chronic discomfort of the hallux MTPJ, necessitating surgical intervention to help alleviate symptoms, according to Dr. Balutis E and Dr., Pino A.(123).Refractory gout in patients who have ongoing symptoms of active disease and cannot maintain a target serum urate less than 6 mg/dl were treated successfully with long-term pegloticase treatment, improvements in clinical status, in the form of flare and tophus reduction and maintained goal range urate-lowering responses during up to 2.5 years of additional treatment(124).

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References

(123) Gout Causing Isolated Sesamoid Destruction Mimicking a Neoplastic Process by Balutis E1, Pino A.(PubMed)

(124) Long-term safety of pegloticase in chronic gout refractory to conventional treatment by Becker MA1, Baraf HS, Yood RA, Dillon A, Vázquez-Mellado J, Ottery FD, Khanna D, Sundy JS.(PubMed)