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Monday, 18 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Gout - Diseases associated with Gout - Diabetes

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                                        Diseases associated with  Gout


According to the UK Gout Society,  diseases associated to gout may include
6. Diabetes
Diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
According to the University of Chicago, diabetic gout patients were older, more frequently female, and had longer gout duration(65).It is said that conventional treatment with 80 mg febuxostat may be more efficacious in female gout subjects with high rates of comorbidities in comparison of commonly prescribed doses of allopurinol(66).
Dr. Donath MY said, " an inflammatory process also seems to be involved in the development of cardiovascular, renal and ophthalmological complications of this disease. Interestingly, several other inflammatory diseases are associated with the metabolic syndrome(particular diabetes) such as psoriasis, gout and rheumatic arthritis"(67).

Recent studies back by renowned institution suggested that Cinnamon(69), Whole Food Papaya(70) and Green Tea(71) reduced Risk and Treatment of Diabetes through their effects in improved fasting blood glucose levels and glucose tolerance without altering the insulin secretion and in regulation of metabolism (carbohydrate, lipid, protein))-medicated glucose and lipid metabolism(68).

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References
(56) Prevalence of gout with comorbidity aggregations in southern Taiwan by Tu FY1, Lin GT2, Lee SS3, Tung YC4, Tu HP5, Chiang HC6.(PubMed)
(57) Lipid abnormalities in Taiwan aborigines with gout by Chou CT1, Chao PM.(PubMed)
(58) A Snack Dietary Pattern Increases the Risk of Hypercholesterolemia in Northern Chinese Adults: A Prospective Cohort Study by Na L1, Han T1, Zhang W1, Wu X1, Na G1, Du S1, Li Y1, Sun C1.(PubMed)
(59) Dietary supplementation contributes to lifestyle improvement in hypercholesterolemic patients in real-life contexts by Bruckert E1, Masana L, Chapman MJ, Descamps O, Bosi E, Allaert FA.(PubMed)
(60) [Studies on association between nonalcoholic fatty liver disease and hyperuricemia: current status and future prospects].[Article in Chinese] by Li YM1.(PubMed)


(65) Diabetes and gout: efficacy and safety of febuxostat and allopurinol by Becker MA1, MacDonald PA, Hunt BJ, Jackson RL.(PubMed)
(66) Women with gout: efficacy and safety of urate-lowering with febuxostat and allopurinol by Chohan S1, Becker MA, MacDonald PA, Chefo S, Jackson RL.(PubMed)
(67) Multiple benefits of targeting inflammation in the treatment of type 2 diabetes by Donath MY1.(PubMed)
(68) The Smoothie of Cinnamon, Whole Food Papaya and Green Tea reduced Risk and Treatment of Diabetes by Kyle J. Norton