Wednesday, 20 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Diseases associated with Gout - Peripheral vascular(artery) disease

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                   Diseases associated with  Gout

According to the UK Gout Society,  diseases associated to gout may include

11. Peripheral vascular(artery) disease 
Peripheral vascular disease is a condition of poor circulation of blood, affecting the  functions of heart and brain. Because of of its implication involving risk of myocardial infarction, stroke, and cardiovascular death and impaired quality of life, some researchers suggested of the importance in identified patients with PAD have become necessary(91). According to the a large cohort of primary care patients, patients with gout are associated to increase risk of vascular disease, particular in female patients with gout(92).
Dr. Baker JF and colleagues at the University of Pennsylvania said, " in multivariate model, a history of gout was associated with an odds ratio of 1.33. Serum uric acid level is independently associated with a higher (but statistically nonsignificant) risk of PAD"(93).
In the study involved classical risk factors and rheological profile of patients suffering from vascular disease of. 364 patients out of a total of 2,498 individuals suffered from vascular disease, the University of Saarland study insisted that patients with gout and metabolic syndrome are associated to elevated risk of peripheral vascular disease(94).

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(91) Peripheral Artery Disease: Evolving Role of Exercise, Medical Therapy, and Endovascular Options by Olin JW1, White CJ2, Armstrong EJ3, Kadian-Dodov D4, Hiatt WR5(PubMed)
(92) Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink by Clarson LE1, Hider SL1, Belcher J1, Heneghan C2, Roddy E1, Mallen CD1.(PubMed)
(93) Serum uric acid level and risk for peripheral arterial disease: analysis of data from the multiple risk factor intervention trial by Baker JF1, Schumacher HR, Krishnan E.(PubMed)
(94) Prevalence, risk factors and rheological profile of arterial vascular disease; first results of the Aachen study by Kiesewetter H1, Jung F, Kotitschke G, Nüttgens HP, Witt R, Winkelhog C, Ladwig KH, Waterloh E, Roebruck P, Schneider R, et al.(PubMed)

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