Thursday, 21 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Kidney stone

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                   The Complications

2. Kidney stone
Kidney stone is a composed of mineral salts formed in the kidneys. Men account for the 80% of those with kidney stones and are at risk of the forming between 30 and 40 years of age. About 75% of kidney stones are calcium stones.
Minimally surgical intervention depends on performing the least invasive technique with the highest success of stone removal, according to Harvard Medical School(107). Others suggests that flexible ureterorenoscopy may be the first-choice treatment for stones <2cm(108).
Dr. Ahmed MH and colleagues at the Milton Keynes Hospital NHS Foundation Trust, believe that Renal stone disease and gallstone disease are the widely prevalent renal stone disease and gallstone disease across the globe, are associated with a variety of diseases including gout(110).
In a total of 396 male patients with gout and 403 age- and sex- matched healthy controls included in this study conducted by the Affiliated Hospital of Qingdao University, risk of renal calculus is increased in patient carrying the TT genotype of CARD8 rs2043211 polymorphism with gout(109).

Recent study by some well known institution suggested that the combination of Green tea(111), Grape (112) and Sweet Potato(113) smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of  kidney Stones  without inducing adverse effects.

If you need more information of the above smoothie, please visits, The Best Smoothie of Green tea, Grape and Sweet Potato for Prevention and Treatment of Kidney Stones caused by Medullary sponge kidney(114).

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(107) Minimally invasive surgical treatment for kidney stone disease by Rodríguez D1, Sacco DE2.(PubMed)
(108) Current practice in Latin America of flexible ureterorenoscopy with laser for treating kidney stones responses on a Latin American questionnaire[Article in English, Spanish] by Manzo BO1, Bertacchi M2, Lozada E3, Rasguido A4, Aleman E5, Cabrera M6, Rodríguez A7, Manzo G3, Sánchez H3, Blasco J8.(PubMed)
(109) CARD8 rs2043211 polymorphism is associated with gout in a Chinese male population by Chen Y1, Ren X, Li C, Xing S, Fu Z, Yuan Y, Wang R, Wang Y, Lv W.(PubMed)
(110) The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome by Ahmed MH1, Barakat S, Almobarak AO.(PubMed)
(111) Effects of green tea on urinary stone formation: an in vivo and in vitro study by Jeong BC1, Kim BS, Kim JI, Kim HH.(PubMed)
(112) 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model by Lee HJ1, Jeong SJ, Lee HJ, Lee EO, Bae H, Lieske JC, Kim SH.(PubMed)
(113) Vitamin E therapy prevents hyperoxaluria-induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status by Thamilselvan S1, Menon M.(PubMed)
(114) The Best Smoothie of Green tea, Grape and Sweet Potato for Prevention and Treatment of Kidney Stones caused by Medullary sponge kidney by Kyle J. Norton

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