Saturday, 23 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Joint damage

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                   The Complications

3. Joint damage
Acute gout or acute gouty arthritis can induce joint damage thoough deposit of uric acid crystals in joint spaces. Patients with gout are associated to complication of joint damage, according to the joint study led by University of Auckland, monosodium urate crystals are frequently present in joints affected by radiographic damage in gout(115).
Dr. Dalbeth N and professors at the University of Auckland in the review of joint damage in aptients with gout, suggested that intensive urate-lowering therapy plays a critical role in improvement in structural damage, particularly bone erosion(116).
MDHAQ (Multidimensional Health Assessment Questionnaire) scores for physical function (FN), pain, Patient Global Estimate (PATGL), and RAPID3 (Routine Assessment of Patient Index Data, a composite of these 3 measures) in the examination of patients with osteoarthritis, systemic lupus erythematosus, spondyloarthropathy, and gout, similarly to rheumatoid arthritis suggested an improvement scores in patients with 5 diagnoses, according to NYU Hospital for Joint Diseases,(117).

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(115) Relationship between structural joint damage and urate deposition in gout: a plain radiography and dual-energy CT study by Dalbeth N1, Aati O1, Kalluru R1, Gamble GD1, Horne A1, Doyle AJ2, McQueen FM3.(PubMed)
(116) Exploratory study of radiographic change in patients with tophaceous gout treated with intensive urate-lowering therapy by Dalbeth N1, Doyle AJ, McQueen FM, Sundy J, Baraf HS.(PubMed)
(117) MDHAQ/RAPID3 to recognize improvement over 2 months in usual care of patients with osteoarthritis, systemic lupus erythematosus, spondyloarthropathy, and gout, as well as rheumatoid arthritis by Castrejón I1, Bergman MJ, Pincus T.(PubMed)

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