Saturday, 23 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Complication of Recurrent gout

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

     The Complications

4. Recurrent gout
Recurrent episodes of gout have shown to induce further damage to joints and other tissues from urate crystal deposition. Certain medication such as aspirin used on two consecutive days is associated with an increased risk of recurrent gout attacks(118). Purine-rich foods intake is associated to increased risk of recurrent gout after 2 days(119).
Consumption of beer, loop or thiazide diuretics, ciclosporin, tacrolimus, ethambutol, pyrazinomide, nicotinic acid, also are found stimulate the progression of recurrent gout, according to Dr. Robin Fox, GP(120). Other risk factors for recurrent gout include medical conditions such as Psoriasis Myeloproliferative disorders, Administration of cytotoxic drugs (tumour lysis syndrome), Inherited enzyme deficiencies and  Lead poisoning(occupations)(120).
Fortunately, in a study of 633 individuals with gout. cherry intake over a 2-day period was associated with a 35% lower risk of gout attacks. Cherry extract intake showed a similar inverse association(121). And according to the University of Maryland School of Medicine, "primary prevention of gout can be achieved through lifestyle changes including weight loss, restricting protein and calorie intake, limiting alcohol consumption, avoiding the use of diuretics in the treatment of hypertension, and avoiding occupational exposure to lead"(122).

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(118) Low-dose aspirin use and recurrent gout attacks by Zhang Y1, Neogi T, Chen C, Chaisson C, Hunter DJ, Choi H.(PubMed)
(119) Purine-rich foods intake and recurrent gout attacks by Zhang Y1, Chen C, Choi H, Chaisson C, Hunter D, Niu J, Neogi T.(PubMed)
(120) Management of recurrent gout by Robin Fox, GP1(PMC)
(121) Cherry consumption and decreased risk of recurrent gout attacks by Zhang Y1, Neogi T, Chen C, Chaisson C, Hunter DJ, Choi HK.(PubMed)
(122) Prevention and management of gout by Star VL1, Hochberg MC.(PubMed)

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