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Friday, 9 October 2015

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine - The Symptoms

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.
A. Symptoms
A.1. Symptoms of Alzheimer's disease
Alzheimer's disease is a brain disorder, affecting over 1 million people in US alone with well known symptoms of lack of concentration (56%), tremors (56%), depression (44%), lack of cooperation (36%), and delusions (32%), psychotic symptoms (delusions, hallucinations, and delirium) and tremors, and emotional symptoms (tearfulness and apathy, lack of concentration and appetite change), according to Hospital de Cruces, Plaza de Cruces s/n, Barakaldo in a study of total of 1014 patients(177). Other symptoms include

1. Increasing forgetfulness(178)
2. Communication difficulty(179)
3. Anxiety(180)
4. Mood and personal change(181)
5. Delay recall(183)
6. Repeat question(183)
7. Memory loss(182)
8 Aberrant motor behavior (184)
9. Sleep problems (184)
10. Eating problems (184) and
11. Agitation/aggression (184)
10. Etc.

A.2. Symptoms of Diminished quality of acetylcholine
If the nerves located in front of the brain perish, diminished quality of acetylcholine, it can cause language difficulty, memory loss, concentration problem and reduce mobile skills because of lacking reaction in muscular activity and refection.
Symptoms of deficiency of acetylcholine include(185)
1. Difficulty remembering names and faces after meeting people
2. Difficulty remembering peoples birthdays and numbers
3. Difficulty remembering lists, directions or instructions
4. Forgetting common facts
5. Trouble understanding spoken or written language
6. Forget where I put things
7. Slowed and/or confused thinking
8. Difficulty finding the right words before speaking
9. Disorientation
10. Prefer to do things alone than in groups / social withdrawal
11. Rarely feel passionate
12. Feel despair and lack joy
13. Lost some of my creativity / lack imagination
14 Dry mouth
15. Etc.

A.3. Dementia due to long-term alcohol abuse
Dementia is common in patients with alcoholism. Most symptoms of alcohol dementia are also presented in other types of dementia, with a few qualitative differences(186) involved both cortical and subcortical pathology. According to the article, "What's alcohol-related dementia?" Alcohol dementia induced deterioration in intellectual function with memory not being specifically affected, such as disinhibition, loss of planning, and executive functionsand a blithe disregard for the consequences of their behaviour, affecting mostly of women in the ages between 30 - 70 with the better rates better than for Korsakoff's Psychosis(187).
Other symptoms in deficits are most frequently observed on tasks of visuospatial function, memory(188) and higher-order (executive) tasks(189)

A.4. Multi-infarct dementia
Also known as vascular dementia, is the second most common form of dementia after Alzheimer's disease in older adults, caused by different mechanisms, affecting the vascular lesions in the brain.with major neurovegetative symptoms of depression accompanied by depressed mood/anhedonia in patients with clinically-diagnosed Alzheimer's disease (AD) and multi-infarct dementia (MID)(190).
Symptoms include memory deficits(192) such as
1. Confusion
2. Memory problems
3. Wandering Getting lost
and
4. At least one of behavioural or psychological symptom, such as appetite disturbances irritability and anxiety and emotional suppresion(such as laughing inappropriately, crying inappropriately)
(193), and
5. Difficulty following instructions, and
6. Bladder incontinence
7. Bowel incontinence(191)

A.5. Dementia associated with Parkinson's disease
Parkinson disease (PD) is a disabling, progressive condition cause of cognitive deficits due to the interruption of frontal-subcortical loops that facilitate cognition and that parallel the motor loop, affecting motor function.These include olfactory deficit, sleep problems such as rapid eye movement behaviour disorder, constipation and male erectile dysfunction.(194).
Other symptoms due to dopamine (DA) deficiency, include, dysexecutive behaviors(196), such as planning, abstract thinking, flexibility and behavioural control and postural disabilities(197) and
1. Constipation
2. Difficulty swallowing
3. Choking, coughing, or drooling
4. Excessive salivation
5. Excessive sweating
6. Loss of bowel and/or bladder control(195)

A.6. Creutzfeldt-Jakob disease (CJD)
People who have eaten contaminated beef in many years, may be infected with Creutzfeldt-Jakob disease (CJD) without even knowing it. Creutzfeldt-Jakob disease is a quickly progressing and fatal disease, characterized by rapidly progressive dementia. Initially, individuals experience problems withmuscular coordination, personality changes, including impaired memory, judgment, and thinking and impaired vision. People with the disease also may experience insomnia, depression, or unusual sensations.(198).

A.7. Subdural hematoma
Subdural hemorrhages, the accumulation of blood beneath the outer cover of the brain resulted from the rupture of blood vessel may cause an increase in tracranial pressure, leading compression and damage to delicate brain tissue. Acute subdural hematoma has a high mortality rate.

A.8. Other symptoms include
1. Intermittent numbness and weakness of extremity(199) and
2. Loss of consciousness(201)
3. Irritability
4. Seizures
5. Pain
6. Headache
7. Dizziness
8. Disorientation
9. Weakness
10. Weakness or lethargy
11. Nausea or vomiting
12. Loss of appetite
13. Personality changes
14. Confused speech
15. Difficulty with balance or walking
16. Altered breathing patterns
17. Hearing loss or hearing ringing (tinnitus)
18. Blurred Vision
19. Deviated gaze, or abnormal movement of the eyes(200)

References
(177) Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment by Fernández M, Gobartt AL, Balañá M; COOPERA Study Group.(PubMed)
(178) Alzheimer's disease and age-related memory decline (preclinical).by Terry AV Jr1, Callahan PM, Hall B, Webster SJ.(PubMed)
(179) Communication Difficulty and Relevant Interventions in Mild Cognitive Impairment: Implications for Neuroplasticity by Johnson M1, Lin F2.(PubMed)
(180) Anxiety and depression in family caregivers of people with Alzheimer disease: the LASER-AD study. by Mahoney R1, Regan C, Katona C, Livingston G.(PubMed)
(181)  Dehydroepiandrosterone (DHEA) supplementation for cognition and well-being. by Huppert FA1, Van Niekerk JK, Herbert J.(PubMed)
(182) How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. by Richardson A1, Galvan V2, Lin AL3, Oddo S4(PubMed)
(183) Evaluation of a Japanese version of the Mini-Mental State Examination in elderly persons. by Ideno Y1, Takayama M, Hayashi K, Takagi H, Sugai Y.(PubMed)
(184) Prevalence of neuropsychiatric symptoms in Alzheimer's disease: a cross-sectional descriptive study in Thailand. by Charernboon T, Phanasathit M.(PubMed)
(185) Behavioral and psychological symptoms of dementia and bipolar spectrum disorders: review of the evidence of a relationship and treatment implications by Dorey JM1, Beauchet O, Thomas Antérion C, Rouch I, Krolak-Salmon P, Gaucher J, Gonthier R, Akiskal HS.(PubMed)
(186) Acetylcholine deficiency(Nutrition healing)
(187) All about dementia(healthcare net)
(188) Association of alcohol drinking with verbal and visuospatial memory impairment in older adults: Clinical Research Center for Dementia of South Korea (CREDOS) study.by Byeon H1, Lee Y2, Lee SY2, Lee KS3, Moon SY4, Kim H5, Hong CH4, Son SJ6, Choi SH7.(PubMed)
(189) Alcohol-related dementia: an update of the evidence. by Ridley NJ1, Draper B2, Withall A3.(PubMed)
(190) [Vascular dementia: big effects of small lesions].[Article in French] by Gold G1, Kövari E.(PubMed)
(191) Symptoms of Multi-Infarct Dementia(Right diagnosis)
(192) The role of neurosonology in the diagnosis of vascular dementia.by Tsivgoulis G1, Katsanos AH2, Papageorgiou SG3, Dardiotis E4, Voumvourakis K3, Giannopoulos S2.(PubMed)
(193) Behavioural and Psychological Symptoms in Poststroke Vascular Cognitive Impairmentby Meena Gupta,* Abhijit Dasgupta, Geeta Anjum Khwaja, Debashish Chowdhury, Yogesh Patidar, and Amit Batra(PubMed)
(194) Non-motor symptoms of Parkinson's disease: diagnosis and management by Salawu FK1, Danburam A, Olokoba AB.(PubMed)
(195) Parkinson’s Disease and Parkinson’s Dementia(Helpguide.org)
(196) Anterior cingulate dopamine turnover and behavior change in Parkinson's disease.by Gallagher CL1, Bell B, Palotti M, Oh J, Christian BT, Okonkwo O, Sojkova J, Buyan-Dent L, Nickles RJ, Harding SJ, Stone CK, Johnson SC, Holden JE.(PubMed)
(197) Biomarkers of Parkinson's disease: present and future. by Miller DB1, O'Callaghan JP2.(PubMed)
(198) Creutzfeldt-Jakob Disease Fact Sheet(NIH)
(199) Chronic subdural hematoma presenting with symptoms of transient ischemic attack (TIA): a case report by Wilkinson CC1, Multani J, Bailes JE.(PubMed)
(200) Subdural hematoma(Medline plus)
(201) COGNITIVE LOSSES ASSOCIATED WITH ALZHEIMER’S(The brain from top to bottom)