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Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.
Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.
Treatments In Herbal Medicine prospective
B. Lemon Palm
Lemon Balm is a perennial plant in the genus Melissa, belonging to the family Lamiaceae, native to southern Europe and the Mediterranean region. The herb has been used in traditional medicine to treat nervous complaints(604), lower abdominal disorders(605) and as anti-inflammatory(608), antivirus(606), antibacterial agent(607).
a. Behavioral and psychological symptoms
According to Newcastle University, lemon balm showed to alleviate behavioral and psychological symptoms in patient with dementia (BPSD)(609), including anxiety(614). Lozenge, containing lavender oil, extracts from hops, lemonbalm and oat showed to induce a state of relaxation and regeneration for better cope with psychological and emotional stress(610)(611) and attenuation of mood and anxiety(612). In behavior symttoms, administraion of combined valerian root and lemon balm extracts, improved symptoms of poor ability to focus decreased from 75% to 14%, hyperactivity from 61% to 13%, and impulsiveness from 59% to 22% as well as general social behavior, sleep symptoms in children(613). On laboratory-induced psychological stress, the standardized M. officinalis extract, a significant increase in the speed of mathematical processing, with no reduction in accuracy(617).
b. Cognitive performance and mood
A standardised M. officinalis preparation administered showed significantly in eradicated mood change and cognitive impairment(614), according to joint study lead by Swinburne University. Acute administration of Melissa officinalis (lemon balm) in high dose, enhanced cognition and mood in both Secondary Memory and Working Memory factors(615)(616), probably through its function in modulation of mood and cognitive performance through lowering both nicotinic and muscarinic binding in healthy humans(616). Due to different preparations derived from the same plant species, some researchers suggested that the effectiveness may exhibit different properties depending on the process used for the sample preparation(616).
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(604) Effects of Melissa officinalis L. (lemon balm) extract on neurogenesis associated with serum corticosterone and GABA in the mouse dentate gyrus by Yoo DY1, Choi JH, Kim W, Yoo KY, Lee CH, Yoon YS, Won MH, Hwang IK.(PubMed)
(605) Inhibitory activity of Melissa officinalis L. extract on Herpes simplex virus type 2 replication. by Mazzanti G1, Battinelli L, Pompeo C, Serrilli AM, Rossi R, Sauzullo I, Mengoni F, Vullo V.(PubMed)
(606) Melissa officinalis oil affects infectivity of enveloped herpesviruses. by Schnitzler P1, Schuhmacher A, Astani A, Reichling J.(PubMed)
(607) Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome by Thompson A1, Meah D, Ahmed N, Conniff-Jenkins R, Chileshe E, Phillips CO, Claypole TC, Forman DW, Row PE.(PubMed)
(608) β-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis Inducer for Tumor Cell Lines. by Amiel E1, Ofir R, Dudai N, Soloway E, Rabinsky T, Rachmilevitch S.(PubMed)
(609) Medicinal plants and dementia therapy: herbal hopes for brain aging by Perry E1, Howes MJ.(PubMed)
(610) Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers by Dimpfel W1, Pischel I, Lehnfeld R.(PubMed)
(611) Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). by Kennedy DO1, Little W, Scholey AB.(PubMed)
(612) Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress by Kennedy DO1, Little W, Haskell CF, Scholey AB.(PubMed)
(613) Hyperactivity, concentration difficulties and impulsiveness improve during seven weeks' treatment with valerian root and lemon balm extracts in primary school children by Gromball J1, Beschorner F2, Wantzen C3, Paulsen U4, Burkart M5.(PubMed)
(614) Anti-stress effects of lemon balm-containing foods. by Scholey A1, Gibbs A2, Neale C3, Perry N4, Ossoukhova A5, Bilog V6, Kras M7, Scholz C8, Sass M9, Buchwald-Werner S10.(PubMed)
(615) Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm) by Kennedy DO1, Scholey AB, Tildesley NT, Perry EK, Wesnes KA.(PubMed)
(616) Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties by Kennedy DO1, Wake G, Savelev S, Tildesley NT, Perry EK, Wesnes KA, Scholey AB.(PubMed)
(617) Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm) by Kennedy DO1, Little W, Scholey AB.(PubMed)