Turmeric Inhibits Tumor Angiogenesis In Vitro

By Kyle J. Norton

Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.

In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the new forming small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.

Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumors proliferation and metastasis".

More precisely, the angiogenesis process a function of a double sword. On one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.

Dr. Papetti M continued, "tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"

Collectively,  " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".

Therefore, by inhibiting the process of blood vessel formation of the tumor, cancer may be curable.

Dr. Dai X, the lead researchers in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibits tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the treatment of cancer, researchers examined the Trivalent arsenic [As(III)] induced damaging effects on human health such as angiogenesis.

Epidemiologically, Trivalent arsenic [As(III)] has been found to induce the development of cardiovascular disease, diabetes, and cancer, and angiogenesis.

According to tested analysis, administration of curcumin, an active ingredient in the dietary turmeric has shown to demonstrate potent antiproliferative, anti-inflammatory by inhibiting the angiogenic activity.

In HCT-116 human colon cancer cells exposed to As(III), both curcumin and turmeric inhibit the expression of vascular endothelial growth factor associated with the promotion of the growth of new blood vessels from the existing blood vessels.

In the chicken chorioallantoic membrane assay model, curcumin or turmeric.also inhibited the extensive increase in blood vessel density.

Based on the findings, researchers wrote, " the findings reported here strongly suggest that turmeric and curcumin can dramatically attenuate the process of angiogenesis induced by low As(III) concentrations".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of cancer-associated with angiogenesis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo by Pantazis P1, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. (PubMed)
(2) Angiogenesis in Cancer by Naoyo Nishida,1,2 Hirohisa Yano,1 Takashi Nishida,3 Toshiharu Kamura,2 andMasamichi Kojiro. (PMC)
(3) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Xingbin Dai,1,2 Pengjun Jiang,2 Yanhua Ji,3 Xuejun Zhu,2 and Xuemei Sun2. (PMC)