Monday, 18 November 2019

Phytochemical Indicaxanthin Exerts a Strong Vascular Protective Effect

By Kyle J. Norton

Blood vessels formed part of the circulatory system that transports blood throughout the body. Arteries and veins are the types of blood vessels that carry blood away from or towards the heart, respectively.

The 3 main types of blood vessels are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body.

Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated in the arterial wall.

Most cases of coronary artery disease are associated with cholesterol building up on the arterial wall found in patients with hypercholesterolemia.

The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with disease of the veins that affects up to 20 percent of adults.

The capillaries or the smallest blood vessels that have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.

Vasoprotection is the process to improve the function of the blood vessels, including the use of the herbal and natural remedy.

Vascular dysfunction associated with dysfunction of large arteries, the microcirculation and endothelium have been found to induce the substantial risk of cardiovascular disease.

Vascular inflammation that causes reduced blood flow to the body due to the changes in the blood vessel walls, including thickening, weakening, narrowing or scarring is also one of the most common cardiovascular risk factors associated with patients with atherosclerosis and hypertension.

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

On finding a potential compound that processes protective vascular effects, researchers examined the effect of Indicaxanthin, a natural chemoactive and chemopreventive agent anti-inflammatory activity, against oxLDL-induced endothelial dysfunction.

According to the results of human umbilical vein cord cells (HUVEC) induced human oxLDL, pretreatment of indicaxanthin in a range between 5 and 20 μM, showed significant inhibition of oxLDL-induced cytotoxicity in a concentration-dependent manner.

Circulating vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) to serve as molecular markers of atherosclerosis and predictors of incident CHD were a significant increase and ABCA1gened associated with the regulation of cellular cholesterol was significantly decreased in the human oxLDL group comapred to pretreatment group.

In other words, the phytochemical exerted protective vascular effects against the incidence of atherosclerosis caused by oxLDL through its antioxidants and anti-inflammatory expression.

Based on the findings, researchers said, "indicaxanthin as a novel, dietary phytochemicals, able to exert significant protective vascular effects in vitro, at nutritionally relevant concentrations".

Taken altogether, indicaxanthin may be considered a protective vascular remedy, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Indicaxanthin from Opuntia ficus indica (L. Mill) Inhibits Oxidized LDL-Mediated Human Endothelial Cell Dysfunction through Inhibition of NF-κB Activation by Attanzio A1, Frazzitta A1, Busa' R1, Tesoriere L1, Livrea MA1, Allegra M. (PubMed)

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