Ulcerative colitis (UC) is a type of inflammatory bowel disease induced chronic inflammation and ulcers (sores) in the digestive tract.
Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
The UC is caused by the immune system mistakenly attacks the cell of the colon, leading to low-grade inflammation.
According to the statistic, in the US, approximately, 1.6 million Americans are living with inflammatory bowel disease, including 907,000 people with ulcerative colitis.
More precisely, the risk of people diagnosed with ulcerative colitis per 100,000 person-years is between 2 and 14.
Conventionally, the treatment of UC is focused on reduced symptoms and prevent the fare up. In some cases, surgery may be necessary if the medication fails.
The exact causes of UC are not identified. Many prevalent factors are associated with UC, including aging, ethnicity, and family. However, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong implication in inducing the rise of ulcerative colitis.
Dr. Patricia Sarlos, the lead scientist in the study of the genetic preposition in the risk of UC, wrote, " Ulcerative colitis (UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals".
And, "Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play a central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease.".
The results strongly link the risk of IBD in people who process the mutated gene inherited from the parent
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of colitis researchers examined the protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in an animal model.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats by Tekeli İO1, Ateşşahin A2, Sakin F3, Aslan A4, Çeribaşı S5, Yipel M. (PubMed)
(2) Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature by Patricia Sarlos, Erzsebet Kovesdi, Lili Magyari, Zsolt Banfai, Andras Szabo, Andras Javorhazy, and Bela Melegh. (PMC)