Herbal Turmeric Processes Anti Colorectal Cancer Activity

By Kyle J. Norton


Colorectum including the large intestine and the rectum is the second part of the digestive system involved in the absorption of water from the small bowel contents and breaks down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colorectal cancer is a medical condition caused by irregular cell growth in the tissue of the colon or rectum.

Most cases of colorectal cancer start in the cells on the surface of the inner lining in the colon and rectum, before penetrating into deeper layers to form a tumor through proliferation.

Colorectal cancer is relatively very common and slowly growing and progresses cancer in a predictable way.

According to the statistics provided by the American Cancer Society, excluding skin cancers, colorectal cancer is the third most common cancer diagnosed in both men and women in the United States. 

In 2019, approximately 101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US.

The 5-year survival rate of colorectal cancer diagnosed at the localized stage is 90%. Sadly, only 39% of patients are diagnosed at this early stage.

The exact causes of colorectal cancer are unknown. Epidemiologically, the most common risk factors associated with the onset of the disease are

* Age
The disease is more common in people over the age of 50.  Regular colonoscopy after age of 50 is valuable to detect the disease in the early stage.

*  Bowl inflammatory diseases
A prolonged period of inflammatory diseases of the colon, such as ulcerative colitis and Crohn’s disease, can increase your risk of colon cancer due to long term inflammation of the lining of the colon.

* Family History of colorectal cancer
People with parents, siblings, children who have had colorectal cancer are more likely to develop colon cancer.

* Inherited Syndromes
Genetic syndromes passed through generations can increase the risk of developing colon cancer.

However, most people with some of the aforementioned prevalent factors have never developed colorectal cancer.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, etc.

With an aim to find a potential compound for the treatment of colorectal cancer, researchers investigated the effects of curcumin nanoformulations anti-cancer activity by overcoming the limitations of the compound.

Application of the nanoformulations not only displayed a greater anticancer activity compared to free curcumin but also extended at the same time non-toxic to the normal cells.

Furthermore, curcumin also demonstrated a strong anti colorectal cancers effect in the regulation of multiple cell signaling pathways associated with tumor growth and anti-apoptosis.

Moreover, curcumin also promoted the expression of tumor suppressor gene which is crucial in cancer development and progression.

The joint study led by the Ahvaz Jundishapur University of Medical Sciences in the examination of curcumin, a bioactive substance originating from turmeric root anticancer properties showed that curcumin inhibited the expression of a gene associated with involved in tumor initiation and progression. In other words, through inhibition of this gene, curcumin reduced the risk of tumor metastasis.

Additionally, by inhibiting the insulin and insulin-like growth factor-1 receptor curcumin showed a greater decrease in the proliferation and migration of chemoresistant colorectal cancer cells.

Based on the results, Dr. Hosseini SA, the lead scientist said, "These results suggest the possible therapeutic effects of curcumin in adjuvant therapy in metastatic colorectal cancer".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells by Hosseini SA1, Zand H2, Cheraghpour M. (PubMed)
(2) Curcumin Nanoformulations for Colorectal Cancer: A Review by Wong KE1,2, Ngai SC3, Chan KG4,5, Lee LH1,2,6, Goh BH1,2,6, Chuah LH. (PubMed)
(3) Bowel (Colorectal ) Cancer by Kyle J. Norton