Saturday, 9 November 2019

Lycopene Reduces the Risk of Gastric Cancer

By Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract.

The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.

Gastrointestinal injury is an injury associated with the stomach, small bowel, colon, or rectum.

In other words, any damage to the organs of the digestive system caused by blunt or penetrating trauma is considered gastrointestinal injury.

Untreated Gastrointestinal injury has been found to increase the risk of cell alternation, leading to the onset of gastric cancer.

Gastric cancer or stomach cancer is a medical condition caused by irregular cell growth of the inner lining tissues of the stomach.

Most cancer of gastric starts in the cells on the inner lining of the stomach before penetrating into deeper layers.

At the advanced stage, cancerous gastric cells can also travel a distance away to an alternate DNA of healthy cells, leading a secondary metastasis.

According to the statistics provided by the Canadian Cancer Society, In 2017, approximately 3,500 Canadians were diagnosed with stomach cancer, and gastric cancer also caused the death of 2,100 including 1,300 women and 790 men.

Hyperproliferation is a progression of highly invasive tumors associated with an abnormally high rate of cancer cell division, leading to rapid overgrowth of the tumor.

The exact causes of gastric/stomach cancer are unidentified. Most common prevalent factors associated with the increasing of age (Most cases of gastric/stomach cancer are found in adults at their fifty), diet, bacterial infection, hydrochloric acid production, long-term inflammation of the stomach, family history and smoking.

However, most people with some of the aforementioned risk factors have never developed gastric. stomach cancer.
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of gastric cancer, researchers examined the role of lycopene by searching MEDLINE and EMBASE to identify potential studies published from January 1966 to June 2012.

According to the mega reports, 21 studies satisfied the inclusion criteria, were identified.
The findings suggested that the consumption of large amounts of tomato products by comparing the highest and lowest consumption groups reduced the risk of gastric cancer.

In other words, the decreased gastric cancer risk was linearly depending on the volume of tomato consumed gaily and regularly.

Additionally, the relative odds ratio risk of gastric cancer was also decreased to 0.88 and 0.79 on lycopene consumption and serum lycopene, respectively.

More precisely, levels of lycopene in the blood induced by chronic intake of tomato were also linearly depending on the amount of consumption daily.

Based on the results, researchers suggested, consumption of large amounts of tomato products daily and regularly induced high levels of lycopene in the blood is associated with a reduced risk of gastric cancer. 

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of gastric cancer, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Anticancer Effect of Lycopene in Gastric Carcinogenesis by Kim MJ1, Kim H. (PubMed)
(2) The role of tomato products and lycopene in the prevention of gastric cancer: a meta-analysis of epidemiologic studies by Yang T1, Yang X, Wang X, Wang Y, Song Z. (PubMed)

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