Healthy Food Turmeric Inhibits Idiopathic Orbital Inflammatory Pseudotumor with No Side Effects

By Kyle J. Norton

The calcifying orbital pseudotumor is a very rare disorder due to a chronic, idiopathic inflammatory process of the orbit.

Most common cases of idiopathic orbital inflammation were found in patients with sclerosing orbital pseudotumor, leading to decreased vision, proptosis, and restriction of extraocular muscles.

Some patients with the condition also experience painful orbital mass.

Women in the middle age are at most risk for the condition onset compared to men.

The exact cause of idiopathic orbital inflammatory pseudotumor is not identified. However,  infection and immune-mediated processes have been postulated by some researchers.

The Harvard Medical School study wrote, "Pathogenesis of idiopathic orbital inflammation remains elusive but several lines of evidence point to immune-mediated processes as the likely underlying ocular mechanism".

Conventionally, most cases of idiopathic orbital inflammation are treated by corticosteroids, particularly in patients in acute cases. 

If treatment with steroids showed a failure, more diagnosed may be needed before methotrexate, cyclophosphamide, and other anti-neoplastic agents may be prescribed. In some cases, patients may also be treated with radiotherapy.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a potential compound for the treatment of orbital inflammatory pseudotumor, researchers examined the clinical efficacy of curcumin, the active constituent of rhizomes of Curcuma longa, in patients suffering from the disease.

According to the tested assays, at a dose of 375 mg/3 times/day, curcumin administered orally for a period of 6-22 months in eight patients and followed up for a period of 2 years at 3 monthly intervals.
* 4 patients recovered completely

* 1 patient showed swelling regressed completely.

* More importantly, patients experienced no side effect and no recurrence during and at the end of the study.

* However, injection of curcumin at the follow up showed some limitation of movement persisted. 

In other words, curcumin is effective for the treatment of idiopathic orbital inflammatory pseudotumor but has a limit success in the improvement of the symptoms of movement.

Based on the finding, researchers at the K.G. Medical College, said, "curcumin could be used as a safe and effective drug in the treatment of idiopathic inflammatory orbital pseudotumors".

Similarly, the University of Texas MD Anderson Cancer Center in the examined the effects of curcumin in patients with idiopathic orbital inflammatory pseudotumor wrote, curcumin (diferuloylmethane), in the various formulations of curcumin, including nanoparticles, liposomal encapsulation, emulsions, capsules, tablets, and powder, are effective for the treatment of idiopathic orbital inflammatory pseudotumor though the inhibition of proinflammatory expression.

Taken altogether, turmeric may be considered supplements for the prevention and treatment of idiopathic orbital inflammatory pseudotumor, pending to the confirmation of the larger sample size and multicenter human study.

Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Role of curcumin in idiopathic inflammatory orbital pseudotumours by Lal B1, Kapoor AK, Agrawal PK, Asthana OP, Srimal RC. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
(3) Idiopathic orbital inflammation: ocular mechanisms and clinicopathology by Yuen SJ1, Rubin PA. (PubMed)
(4) Idiopathic orbital inflammatory disease by Mary K. Jacob. (PMC)