Sunday, 17 November 2019

Herbal Turmeric, the Natural Prevention and Treatment of Colitis

By Kyle J. Norton

Colitis is a condition associated with inflammation of the inner lining of the colon.

There is no exact cause of colitis. Certain risk factors such as colon infection, inflammatory bowel disease (Crohn's disease, ulcerative colitis), ischemic colitis, allergic reactions, and microscopic colitis have been found to increase the risk of the onset of the condition.

Most common symptoms of colitis are totally depending on the types, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

Types of colitis according to the  Catholic University of the Sacred Heart, are including
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.

Epidemiologically, people with untreated colitis may experience complications of

* Congenital abnormalities
Women who are pregnant with Ulcerative colitis are associated with significantly increased risk of some selected congenital abnormalities (limb deficiencies, obstructive urinary, and multiple congenital abnormalities) according to the birth outcomes in women with ulcerative colitis examined in a nationwide.

* Nutritional deficiency
Malnutrition, particularly protein-energy malnutrition and vitamin and micronutrient deficiencies, as well as dysregulation of the intestinal microbiota, are common features of IBD.

Conventionally, besides treating colitis with antibiotics, certain medications also are prescribed to improve the symptoms and quality of life of the patients, inclduing anti-diarrheal medications.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of colitis, researchers examined the effects of novel gut health product (GHP), an encapsulation of asafoetida (ASF) and CUR complex used as a carrier agent to encapsulate bioactive components for the treatment of colitis.

According to the rat model of 5%, dextran sulfate sodium (DSS) induced UC, treatment of GHP significantly attenuated the disease activity index, colitis score, histopathological changes, and myeloperoxidase activity.

Furthermore, GHP also demonstrated significant protective effects against DSS induced colitis.

Additionally, also in an animal model of dextran sodium sulfate (DSS)-induced colitis, a specific, curcumin preparation containing essential turmeric oils (ETO-curcumin) compared to standard curcumin at three specific doses (0, 5, 25 or 50 mg/kg), both ETO and standard curcumin treatments provided protection against DSS-induced inflammation.

However, according to the tested assays, ETO-curcumin improved disease activity index (DAI) dose-dependently, compared the anti-inflammatory efficacy of standard curcumin remained constant.

In other words, ETO-curcumin was more superior in the expression of anti-inflammatory efficacy compared to standard curcumin.

Moreover, ETO-curcumin displayed anti colitis activity in the colon by exerting anti-inflammatory cytokines including IL-10 and IL-11 as well as FOXP3.

Collectively, Dr. Toden S., the lead scientist, wrote at the final report, " the combined treatment of curcumin and essential turmeric oils provides superior protection from DSS-induced colitis than curcumin alone, highlighting the anti-inflammatory potential of turmeric".

Taken altogether, turmeric plus essential turmeric oils may be considered supplements for the prevention of colitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber by Gopi S1, Amalraj A2, Jude S2, Varma K2, Sreeraj TR2, Haponiuk JT3, Thomas S. (PubMed)
(2) Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis by Toden S1, Theiss AL2, Wang X3, Goel A. (PubMed)
(3) Colitis - The Complications by Kyle J. Norton

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